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C-Reactive Protein (CRP) antibody

Details for Product No. ABIN249461
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Antigen
Reactivity
Human
(395), (40), (34), (19), (14), (6), (5), (4), (1)
Host
Goat
(208), (106), (83), (36), (6), (5), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(30), (18), (17), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(272), (208), (59), (46), (22), (20), (20), (19), (18), (14), (11), (9), (9), (7), (7), (7), (6), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 7 references available
Quantity 0.1 mL
Shipping to United States (Change)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN249461
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Immunogen Human recombinant C-Reactive protein
Specificity It has been shown to be specific for C-reactive protein by WB.
Cross-Reactivity (Details) other species have not yet been tested.
Purification Whole antisera
Background FUNCTION: Displays several functions associated with host defense: it promotesagglutination, bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to hosphorylcholine. Can interact with DNA and histonesand may scavenge nuclear material released from damaged circulating cells.COFACTOR: Binds 2 calcium ions per subunit. SUBUNIT: Homopentamer. Pentaxin (orpentraxin) have a discoid arrangement of 5 non-covalently bound subunits.SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 namedisoforms produced by alternative splicing. TISSUE SPECIFICITY: Found in plasma.INDUCTION: The concentration of CRP in plasma increases greatly during acute phaseresponse to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 andIL-6. MISCELLANEOUS: This protein owes its name to its ability precipitatepneumococcal C-polysaccharide in the presence of calcium. SIMILARITY: Belongs tothe pentaxin family. SIMILARITY: Contains 1 pentaxin domain. Alternate Names: anti-GENE NAME: CRP antibody, anti-PTX1 antibody. Related Diseases: Inflammatory Markers
Gene Symbol: CRP
Gene ID 1401
Research Area Serum/Plasma Proteins, Inflammation
Application Notes Western Blot. Extremely high titer antibody. For western blot a dilution of 1: 10,000 to 1: 100,000 is recommended.
Recommended dilutions: Western Blot 1:10000 - 1:100000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
General Oliveira, Gotschlich, Liu: "Primary structure of human C-reactive protein." in: The Journal of biological chemistry, Vol. 254, Issue 2, pp. 489-502, 1979 (PubMed).

Lei, Liu, Zon et al.: "Genomic DNA sequence for human C-reactive protein." in: The Journal of biological chemistry, Vol. 260, Issue 24, pp. 13377-83, 1985 (PubMed).

Tucci, Goldberger, Whitehead et al.: "Biosynthesis and postsynthetic processing of human C-reactive protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 5, pp. 2416-9, 1983 (PubMed).

Whitehead, Bruns, Markham et al.: "Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1." in: Science (New York, N.Y.), Vol. 221, Issue 4605, pp. 69-71, 1983 (PubMed).

Srinivasan, White, Emsley et al.: "Comparative analyses of pentraxins: implications for protomer assembly and ligand binding." in: Structure (London, England : 1993), Vol. 2, Issue 11, pp. 1017-27, 1995 (PubMed).

Shrive, Cheetham, Holden et al.: "Three dimensional structure of human C-reactive protein." in: Nature structural biology, Vol. 3, Issue 4, pp. 346-54, 1996 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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