C-Reactive Protein (CRP) antibody

Antigen: C-Reactive Protein (CRP)

Synonyms: PTX1, MGC88244, MGC149895, AI255847, Aa1249, Ac1262, Ab1-341, Ab2-196, Ac1-114, Ac2-069, Ba2-693, CRP, crp

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN249461

Additional Information

Gene ID: 1401

Immunogen: Human recombinant C-Reactive protein.

Cross-Reactivity: Human

Description: FUNCTION: Displays several functions associated with host defense: it promotesagglutination, bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to hosphorylcholine. Can interact with DNA and histonesand may scavenge nuclear material released from damaged circulating cells.COFACTOR: Binds 2 calcium ions per subunit. SUBUNIT: Homopentamer. Pentaxin (orpentraxin) have a discoid arrangement of 5 non-covalently bound subunits.SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 namedisoforms produced by alternative splicing. TISSUE SPECIFICITY: Found in plasma.INDUCTION: The concentration of CRP in plasma increases greatly during acute phaseresponse to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 andIL-6. MISCELLANEOUS: This protein owes its name to its ability precipitatepneumococcal C-polysaccharide in the presence of calcium. SIMILARITY: Belongs tothe pentaxin family. SIMILARITY: Contains 1 pentaxin domain. Alternate Names: anti-GENE NAME: CRP antibody, anti-PTX1 antibody. Related Diseases: Inflammatory Markers

Specificity: It has been shown to be specific for C-reactive protein by WB. Species Reactivity: Human, other species have not yet been tested. Localization: Accession Number: CRP_HUMAN.

Application Details

Application Notes: Western Blot. Extremely high titer antibody. For western blot a dilution of 1: 10,000 to 1:100,000 is recommended. The optimal dilution should be determined by the end user.

Buffer: Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.

Research Area: Serum/Plasma Proteins, Inflammation

Restrictions: For Research Use only

Publications

Oliveira, Gotschlich, Liu: "Primary structure of human C-reactive protein." in: The Journal of biological chemistry, Vol. 254, Issue 2, pp. 489-502, 1979 (PubMed).

Lei, Liu, Zon et al.: "Genomic DNA sequence for human C-reactive protein." in: The Journal of biological chemistry, Vol. 260, Issue 24, pp. 13377-83, 1985 (PubMed).

Tucci, Goldberger, Whitehead et al.: "Biosynthesis and postsynthetic processing of human C-reactive protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 5, pp. 2416-9, 1983 (PubMed).

Whitehead, Bruns, Markham et al.: "Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1." in: Science (New York, N.Y.), Vol. 221, Issue 4605, pp. 69-71, 1983 (PubMed).

Srinivasan, White, Emsley et al.: "Comparative analyses of pentraxins: implications for protomer assembly and ligand binding." in: Structure (London, England : 1993), Vol. 2, Issue 11, pp. 1017-27, 1995 (PubMed).

Shrive, Cheetham, Holden et al.: "Three dimensional structure of human C-reactive protein." in: Nature structural biology, Vol. 3, Issue 4, pp. 346-54, 1996 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).