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Details for Product No. ABIN249461

C-Reactive Protein (CRP) antibody

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Antigen
Synonyms PTX1, AI255847, Aa1249, Ac1262, Ab1-341, Ab2-196, Ac1-114, Ac2-069, Ba2-693, APCS, crp
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN249461
Quantity 0.1 mL
Price
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Immunogen Human recombinant C-Reactive protein.
Specificity It has been shown to be specific for C-reactive protein by WB. Species Reactivity: Human, other species have not yet been tested. Localization: Accession Number: CRP_HUMAN.
Cross-Reactivity Human
Background FUNCTION: Displays several functions associated with host defense: it promotesagglutination, bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to hosphorylcholine. Can interact with DNA and histonesand may scavenge nuclear material released from damaged circulating cells.COFACTOR: Binds 2 calcium ions per subunit. SUBUNIT: Homopentamer. Pentaxin (orpentraxin) have a discoid arrangement of 5 non-covalently bound subunits.SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 namedisoforms produced by alternative splicing. TISSUE SPECIFICITY: Found in plasma.INDUCTION: The concentration of CRP in plasma increases greatly during acute phaseresponse to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 andIL-6. MISCELLANEOUS: This protein owes its name to its ability precipitatepneumococcal C-polysaccharide in the presence of calcium. SIMILARITY: Belongs tothe pentaxin family. SIMILARITY: Contains 1 pentaxin domain. Alternate Names: anti-GENE NAME: CRP antibody, anti-PTX1 antibody. Related Diseases: Inflammatory Markers
Gene ID 1401
Research Area Serum/Plasma Proteins, Inflammation
Application Notes Western Blot. Extremely high titer antibody. For western blot a dilution of 1: 10,000 to 1:100,000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Oliveira, Gotschlich, Liu: "Primary structure of human C-reactive protein." in: The Journal of biological chemistry, Vol. 254, Issue 2, pp. 489-502, 1979 (PubMed).

Lei, Liu, Zon et al.: "Genomic DNA sequence for human C-reactive protein." in: The Journal of biological chemistry, Vol. 260, Issue 24, pp. 13377-83, 1985 (PubMed).

Tucci, Goldberger, Whitehead et al.: "Biosynthesis and postsynthetic processing of human C-reactive protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 5, pp. 2416-9, 1983 (PubMed).

Whitehead, Bruns, Markham et al.: "Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1." in: Science (New York, N.Y.), Vol. 221, Issue 4605, pp. 69-71, 1983 (PubMed).

Srinivasan, White, Emsley et al.: "Comparative analyses of pentraxins: implications for protomer assembly and ligand binding." in: Structure (London, England : 1993), Vol. 2, Issue 11, pp. 1017-27, 1995 (PubMed).

Shrive, Cheetham, Holden et al.: "Three dimensional structure of human C-reactive protein." in: Nature structural biology, Vol. 3, Issue 4, pp. 346-54, 1996 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Alternatives for antigen "C-Reactive Protein (CRP)", type "Antibodies"
Hosts (215), (115), (83), (40), (6), (6), (2), (1), (1)
Reactivities (417), (43), (37), (19), (15), (7), (6), (5)
Applications (297), (225), (59), (47), (28), (21), (20), (20), (14), (12), (12), (9), (8), (8), (8), (7), (6), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (36), (21), (17), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (15), (6), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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