Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (C-Term), (AA 489-501) antibody

Details for Product No. ABIN249942
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Antigen
Synonyms FOXC2, Fkh14, Hfhbf3, MFH-1, Mfh1, Fkhl14, FKHL14, LD, MFH1
Epitope
C-Term, AA 489-501
(8), (8), (7), (7), (7), (7), (5), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(74), (20), (19), (14), (13), (4)
Host
Goat
(41), (28), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA
(65), (44), (19), (17), (10), (8), (7), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN249942
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Immunogen Synthetic peptide: RHAAPYSYDCTKY representing the C-Terminus of the human protein (residues 489-501), according to NP_005242
Isotype IgG
Cross-Reactivity (Details) Mouse reactivity reported in the scientific literature (PMID: 23862012). Expected cross reactivity from sequence similarity: Rat, Dog,Cow.
Purification affinity purified
Alternative Name FOXC2 / FKHL14 / MFH1
Background FOXC2 belongs to the forkhead family of transcription factors which is characterized bya distinct DNA binding forkhead domain. The specific function of this gene has not yetbeen determined, however, it may play a role in the development of mesenchymaltissues. Alternate Names: anti-FOXC2 antibody, anti-MFH1 antibody, anti-MFH-1 antibody, anti-FKHL14 antibody,anti-forkhead box C2 (MFH-1 antibody, anti-mesenchyme forkhead 1)antibody,anti-MFH-1 antibody, mesenchyme forkhead 1 antibody, anti-forkhead (Drosophila)-like14 antibody, anti-forkhead antibody, anti-Drosophila antibody, anti-homolog-like 14antibody, anti-forkhead (Drosophila)-like 14 (MFH-1 antibody, anti-mesenchymeforkhead 1) antibody, anti-Official Symbol antibody, anti-FOXC2 antibody.
Gene Symbol: FOXC2
Gene ID 2303, 14234
NCBI Accession NP_005242
Application Notes Approx 50-55 kDa band observed in Human Breast Cancer lysates (calculated MW of 53.7kDa according to NP_005242.1). Use in ICC/IF and IHC-Fr was reported in the scientific literature (PMID: 23862012).
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:10-1:2000, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Frozen 1:10-1:2000, Peptide ELISA detection limit 1:8000, Western Blot 1-3 µg/mL
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline containing [pH 7.3] with 0.5 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (C-Term), (AA 489-501) antibody Western Blot: FOX C2 Antibody [ABIN249942] - ABIN249942 staining (1ug/ml) of Human Breast Cancer lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
General Brice, Mansour, Bell et al.: "Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24." in: Journal of medical genetics, Vol. 39, Issue 7, pp. 478-83, 2002 (PubMed).

Dagenais, Hartsough, Erickson et al.: "Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome." in: Gene expression patterns : GEP, Vol. 4, Issue 6, pp. 611-9, 2004 (PubMed).

Zarbalis, Siegenthaler, Choe et al.: "Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 35, pp. 14002-7, 2007 (PubMed).

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