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Clock Homolog (Mouse) (CLOCK) antibody

Antigen

Clock Homolog (Mouse) (CLOCK)
Synonyms KAT13D, bHLHe8, KIAA0334, mKIAA0334, 5330400M04Rik, clk, Xclk, XClock, CLOCK, DKFZp469L011, zCLOCK1, zfCLOCK1, CLK, Jerk, Jrk, PAS1, dCLK, dCLK/JRK, dCLOCK, dClck, DmelCG7391, CG7391
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunoprecipitation (IP), Western Blotting (WB)
4 references available
Catalog no. ABIN249944
Quantity 25 µl  (Variants)
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name CLOCK
Gene ID 12753
Immunogen Two peptides derived from mouse CLOCK, conjugated to albumin.
Cross-Reactivity Human
Format Serum
Description CLOCK, a basic helix-loop-helix (bHLH)/PAS protein, is an important factor in themolecular clock mechanism. Mutations in this protein lead to abnormal circadianbehavior and defective transcriptional activity. CLOCK has been shown to interactstrongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform. Alternate Names: anti-KIAA0334 antibody.
Specificity This antibody is specific for mCLOCK. Species Reactivity: Peptide 1 shows significant homology to human and Gallus gallus. Peptide 2 shows82% homology to Gallus gallus.

Application Details
Publications Alternatives Variants back to top

Application Notes Western blotting (suggested working dilution 1:1,000). Antisera was tested againstbacterially expressed fragment of CLOCK expressed in BL21 cells or the full lengthprotein expressed in an in vitro translation system (reticulocyte lysate).Also works for ChIP Assay (request specific protocol if needed).
Purification Serum
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors, Metabolism
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Hogenesch, Gu, Jain et al.: "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 10, pp. 5474-9, 1998 (PubMed).

Jin, Shearman, Weaver et al.: "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock." in: Cell, Vol. 96, Issue 1, pp. 57-68, 1999 (PubMed).

Shearman, Weaver: "Photic induction of Period gene expression is reduced in Clock mutant mice." in: Neuroreport, Vol. 10, Issue 3, pp. 613-8, 1999 (PubMed).

Muunoz, Brewer, Baler: "Circadian Transcription. Thinking outside the E-Box." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36009-17, 2002 (PubMed).