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Details for Product No. ABIN249944

Clock Homolog (Mouse) (CLOCK) antibody

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KAT13D, bHLHe8, mKIAA0334, 5330400M04Rik, clk, Xclk, XClock, CG7391, CLK, CLOCK, Dmel\\CG7391, Jerk, Jrk, PAS1, bHLHe10, clock, dCLK, dCLK/JRK, dCLOCK, dClck, dClk, dClock, dclk, jrk, zCLOCK1, zfCLOCK ... show more
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN249944
Quantity 25 µL
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Immunogen Two peptides derived from mouse CLOCK, conjugated to albumin.
Specificity This antibody is specific for mCLOCK. Species Reactivity: Peptide 1 shows significant homology to human and Gallus gallus. Peptide 2 shows82% homology to Gallus gallus.
Cross-Reactivity Human
Purification Serum
Alternative Name CLOCK
Background CLOCK, a basic helix-loop-helix (bHLH)/PAS protein, is an important factor in themolecular clock mechanism. Mutations in this protein lead to abnormal circadianbehavior and defective transcriptional activity. CLOCK has been shown to interactstrongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform. Alternate Names: anti-KIAA0334 antibody.
Gene ID 12753
Research Area Cardiovascular, Atherosclerosis, Transcription Factors, Metabolism
Application Notes Western blotting (suggested working dilution 1:1,000). Antisera was tested againstbacterially expressed fragment of CLOCK expressed in BL21 cells or the full lengthprotein expressed in an in vitro translation system (reticulocyte lysate).Also works for ChIP Assay (request specific protocol if needed).
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Hogenesch, Gu, Jain et al.: "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 10, pp. 5474-9, 1998 (PubMed).

Jin, Shearman, Weaver et al.: "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock." in: Cell, Vol. 96, Issue 1, pp. 57-68, 1999 (PubMed).

Shearman, Weaver: "Photic induction of Period gene expression is reduced in Clock mutant mice." in: Neuroreport, Vol. 10, Issue 3, pp. 613-8, 1999 (PubMed).

Muunoz, Brewer, Baler: "Circadian Transcription. Thinking outside the E-Box." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36009-17, 2002 (PubMed).

Alternatives for antigen "Clock Homolog (Mouse) (CLOCK)", type "Antibodies"
Hosts (51), (10), (1)
Reactivities (54), (36), (27), (12), (11), (11), (11), (1), (1), (1)
Applications (47), (25), (9), (8), (7), (4), (3), (3), (3), (2), (2), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (5), (4), (2), (1), (1), (1), (1), (1), (1)