UBE3C antibody (N-Term)

Catalog No. ABIN2500926

Product Details anti-UBE3C Antibody

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE3C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MFSFEGDFKT RPKVSLGGAS RKYSIQRSAF DRCATLSQSG GAFPIANGPN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against UBE3C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human UBE3C

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UBE3C

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Alternative Name: UBE3C (UBE3C Products)

Synonyms: UBE3C antibody, RGD1559986 antibody, zgc:63649 antibody, AI853514 antibody, mKIAA0010 antibody, HECTH2 antibody, kiaa0010 antibody, MGC146390 antibody, ubiquitin protein ligase E3C antibody, ubiquitin protein ligase E3C S homeolog antibody, UBE3C antibody, Ube3c antibody, ube3c antibody, ube3c.S antibody

Background: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. UBE3C can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. It has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Protein Interaction Partner: UBC, GOLGA2, PSMD14, SHFM1, UBE2D1, PSMD2, PSMC5, PANK4, EEF2K, WDR92, TLK1, MTA2, ECT2, CPEB4, THOC7, RBM15, THOC2, WDR74, KDM1A, USP13, UTRN, PHKA2, APP, UBE2L3, UBE3C, PSMA2, ELAVL1, RAD21, MYC, CAND2, PSMD6,
Protein Size: 404

Molecular Weight: 44 kDa

Gene ID: 9690