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Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 2 (CITED2) antibody

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(57), (21), (14), (4), (2), (2), (1), (1), (1)
(38), (16), (4), (2), (1)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (3), (3), (3)
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(42), (39), (11), (7), (3), (1), (1)
Pubmed 7 references available
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Quantity 25 μL
Shipping to United States ( )
Immunogen Human CITED 2 protein
Clone JA22
Isotype IgG1 kappa
Purification Ascites
Alternative Name CITED2 (CITED2 Antibody Abstract)
Background Cited 2 is a cAMP-responsive element-binding protein (CBP)/p300 interactingtranscriptional modulator and a proposed negative regulator for hypoxia-induciblefactor-1 alpha. Recruitment of CBP/p300 by HIF-1 is essential for the transcriptionalresponse to hypoxia. Alternate Names: anti-CITED2 antibody, anti-Cbp/p300-interacting transactivator antibody, anti-withGlu/Asp-rich carboxy-terminal domain antibody, anti-2antibody, anti-HGNC:1987antibody, anti-MRG1 antibody, anti-P35SRJ antibody, anti-CITED 2 antibody.
Gene Symbol: CITED2
Gene ID 10370
UniProt Q99967
Research Area Cancer
Application Notes This CITED2 (JA22) antibody is useful in Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at 29 kDa. Additional bands may be seen at 36 kDa representing p35srj, Use in Immunohistochemistry-paraffin reported in scientific literature (PMID: 19319572) the alternatively spliced version of CITED2, and at 70 kDa (unknown). Does not work well on mouse tissue.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:100-1:500, Immunohistochemistry-Paraffin, Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Product cited in: Dabir, Marinic, Krukovets et al.: "Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells." in: Circulation research, Vol. 102, Issue 12, pp. 1558-65, 2008 (PubMed).

Haase, Schott, Bornstein et al.: "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor." in: The Journal of endocrinology, Vol. 192, Issue 2, pp. 459-65, 2007 (PubMed).

Bamforth, Bragança, Farthing et al.: "Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway." in: Nature genetics, Vol. 36, Issue 11, pp. 1189-96, 2004 (PubMed).

Tien, Davis, Vanden Heuvel: "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24053-63, 2004 (PubMed).

Yin, Haynie, Yang et al.: "The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 16, pp. 10488-93, 2002 (PubMed).

Leung, Jones, Michels et al.: "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1." in: Genomics, Vol. 61, Issue 3, pp. 307-13, 2000 (PubMed).

Background publications Bhattacharya, Michels, Leung et al.: "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1." in: Genes & development, Vol. 13, Issue 1, pp. 64-75, 1999 (PubMed).

Catalog No. ABIN250128
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