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LRP6 antibody (Low Density Lipoprotein Receptor-Related Protein 6) (AA 1546-1560)

Details for Product anti-LRP6 Antibody No. ABIN250317, Supplier: Log in to see
Antigen
  • lrp6-A
  • Xlrp6
  • adcad2
  • lrp6
  • LRP6
  • ADCAD2
  • C030016K15Rik
  • Cd
  • Gw
  • low density lipoprotein receptor-related protein 6
  • low-density lipoprotein receptor-related protein 6
  • LRP6
  • lrp6-A
  • lrp6-b
  • lrp6
  • Lrp6
Alternatives
anti-Human LRP6 antibody for ELISA
Epitope
AA 1546-1560
15
15
12
12
8
7
5
5
2
1
1
1
1
1
Reactivity
Human
91
22
5
3
1
1
1
1
1
1
Host
Goat
59
18
14
1
Clonality
Polyclonal
Conjugate
This LRP6 antibody is un-conjugated
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), ELISA
35
32
32
20
19
14
13
3
3
2
1
1
Options
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Immunogen Peptide with sequence CMTSVATAKGYTSDL corresponding to internal region according to NP_002327.2.
Specificity This antibody is expected to recognise an epitope corresponding to aa 1546-1560 of human LRP6 protein.
Purification Immunogen affinity purified
Alternative Name LRP-6 (LRP6 Antibody Abstract)
Background Gene Symbol: LRP6
Gene ID 4040
UniProt O75581
Pathways WNT Signaling, Tube Formation
Application Notes Immunohistochemistry 4 - 6 μg/mL, Immunohistochemistry-Paraffin 4 - 6 μg/mL, Peptide ELISA Detection limit 1:64000WB: Preliminary experiments gave bands at approx. 50 kDa band and 35 kDa band in human adipose lysates after 0.1 μg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 180 kDa band according to NP_002327.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands). IHC-P: Human kidney shows luminar membrane staining in DCT.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 0.5 mg/mL Tris ( pH 7.3) and 0.5 % BSA
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-LRP6 antibody (Low Density Lipoprotein Receptor-Related Protein 6) (AA 1546-1560) (ABIN250317) Immunohistochemistry: LRP6 Antibody [ABIN250317] - ABIN250317 (5ug/ml) staining of pa...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-LRP6 antibody (Low Density Lipoprotein Receptor-Related Protein 6) (AA 1546-1560) (ABIN250317) Immunohistochemistry-Paraffin: LRP-6 Antibody [ABIN250317] - Analysis of paraffin emb...
Product cited in: Liu, Mani, Davis, Sarrafzadegan, Kavathas, Mani: "Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance." in: Circulation research, Vol. 103, Issue 11, pp. 1280-8, 2008 (PubMed).

Tamai, Semenov, Kato, Spokony, Liu, Katsuyama, Hess, Saint-Jeannet, He: "LDL-receptor-related proteins in Wnt signal transduction." in: Nature, Vol. 407, Issue 6803, pp. 530-5, 2000 (PubMed).