Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) antibody

Details for Product No. ABIN250317
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Antigen
Synonyms ADCAD2, C030016K15Rik, Cd, Gw, lrp6-A, Xlrp6, adcad2, lrp6, LRP6
Reactivity
Human
(70), (43), (42), (41), (41), (31), (12), (12), (1)
Host
Goat
(66), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
(31), (30), (26), (24), (14), (8), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN250317
Quantity 0.1 mg
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Immunogen Synthetic Peptide CMTSVATAKGYTSDL, representing the internal region of the humanprotein (residues 1546-1560), according to NP_002327. Reference Sequence: NP_002327.
Isotype IgG
Specificity Species Reactivity: Human. Predicted to react with Mouse, Rat, Chicken. Not yet tested in other species.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name LRP6
Background LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as acoreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/betacatenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis. Alternate Names: anti-Low density lipoprotein receptor related protein 6 antibody.
Gene ID 4040
NCBI Accession NP_002327
Research Area Stem Cells, Cancer
Application Notes Suggested working dilutions: ELISA 1:64000,Western Blot 0.1ug/ml,Immunohistochemistry-Paraffin 5-10ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris-saline containing [pH7.3] with 0.5% BSA. Preservative: 0.02%Na azide.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) antibody Immunohistochemistry: LRP6 Antibody [ABIN250317] - ABIN250317 (5ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
General Tamai, Semenov, Kato et al.: "LDL-receptor-related proteins in Wnt signal transduction." in: Nature, Vol. 407, Issue 6803, pp. 530-5, 2000 (PubMed).

Liu, Mani, Davis et al.: "Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance." in: Circulation research, Vol. 103, Issue 11, pp. 1280-8, 2008 (PubMed).

Hosts (66), (6), (2)
Reactivities (70), (43), (42), (41), (41), (31), (12), (12), (1)
Applications (31), (30), (26), (24), (14), (8), (3), (2), (2), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Epitopes (13), (13), (6), (4), (3), (2), (1), (1)
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