Peptidyl Arginine Deiminase, Type IV (PADI4) antibody

Details for Product No. ABIN250318
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Antigen
Synonyms PAD, PAD4, PDI4, PDI5, PADI5, Pad4, Pdi4
Reactivity
Human
(61), (7), (7), (1), (1), (1), (1), (1), (1)
Host
Goat
(46), (11), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(52), (26), (16), (13), (10), (8), (7), (5), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN250318
Quantity 0.1 mg
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Immunogen Synthetic peptide AQGTLIRVTPEQPC, representing the N-Terminus of the humanprotein (residues 2-15), according to NP_036519. Reference Sequence: NP_036519.
Isotype IgG
Specificity Species Reactivity: Reacts with Human. Not yet tested in other species.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name PADI4
Background In vivo expression of PADI4 correlated with the appearance of citrulline in histones. Wehave shown that PADI4 converts arginines in the histone H3 tail to citrulline, that PADI4blocks transcriptional activation and is recruited to the endogenous promotor. PADI4represents a novel class of histone modifying enzymes probably linked to eostrogenregulated transcription. Alternate Names: anti-EC 3.5.3.15 antibody, anti-HL 60 PAD antibody, anti-PADI5 antibody, anti-PDI5antibody, anti-Peptidylarginine deiminase IV antibody, anti-Protein arginine deiminasetype IV antibody. Related Diseases: Rheumatoid Arthritis
Gene ID 23569
NCBI Accession NP_036519
Application Notes This antibody can be used for ELISA and Western Blot. In Western Blot, approx 74kDaband observed in Human Spleen and Human Liver lysates (calculated MW of 74.1kDaaccording to NP_036519). Recommended Starting Dilution:*ELISA (peptide): 1:64,000WB: 0.3-2ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) antibody ABIN250318 (0.3µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).

Liu, Mani, Davis et al.: "Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance." in: Circulation research, Vol. 103, Issue 11, pp. 1280-8, 2008 (PubMed).

Hosts (46), (11), (5)
Reactivities (61), (7), (7), (1), (1), (1), (1), (1), (1)
Applications (52), (26), (16), (13), (10), (8), (7), (5), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (4), (2), (2), (2), (1), (1), (1), (1)
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