Apolipoprotein E (APOE) antibody

Details for Product No. ABIN250408
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Antigen
Synonyms AD2, LDLCQ5, LPG, AI255918, APOEA, Apo-E, ad2, apoprotein, im:7036787, wu:fb69a05, zgc:110064, apoe
Reactivity
Human
(171), (41), (31), (5), (4), (2), (2), (2), (1)
Host
Goat
(101), (65), (51), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (7), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(158), (131), (50), (42), (20), (18), (16), (12), (11), (9), (8), (7), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN250408
Quantity 0.1 mg
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Immunogen Synthetic peptide with sequence C-VGTSAAPVPSDNH, representing the C Terminus ofthe human protein according to NP_000032.1. Reference Sequence: NP_000032.1.
Isotype IgG
Specificity This antibody is specific for APOE. Species Reactivity: Human, Chimpanzee.
Cross-Reactivity Human, Monkey
Purification Affinity Purified
Alternative Name Apolipoprotein E (Apo E)
Background Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidlyremoved from the circulation by receptor-mediated endocytosis in the liver.Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor onliver cells and peripheral cells. ApoE is essential for the normal catabolism oftriglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familialdysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increasedplasma cholesterol and triglycerides are the consequence of impaired clearance ofchylomicron and VLDL remnants. Alternate Names: anti-APOE antibody, anti-AD2 antibody, anti-MGC1571 antibody, anti-apoproteinantibody, anti-apolipoprotein E antibody, anti-apolipoprotein E3 antibody, anti-Alzheimerdisease 2 (APOE*E4-associated antibody, anti-late onset antibody.
Gene ID 348
NCBI Accession NP_0000321
Research Area Metabolism
Application Notes This antibody can be used in ELISA and Western Blot where a 36kDa band has beenobserved in Human Brain lysates. Predicted MW is 36.2kDa according toNP_000032.1). Recommended dilutions: ELISA 1/32,000. WB: 0.1-0.3ug/ml. *Optimaldilutions should be determined by the end user.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline containing 0.02% sodium azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Apolipoprotein E (APOE) antibody Western Blot: APOE Antibody [ABIN250408] (0.1ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer).
General Dodart, Marr, Koistinaho et al.: "Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 4, pp. 1211-6, 2005 (PubMed).

Hosts (101), (65), (51), (1)
Reactivities (171), (41), (31), (5), (4), (2), (2), (2), (1)
Applications (158), (131), (50), (42), (20), (18), (16), (12), (11), (9), (8), (7), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Conjugates (13), (7), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Epitopes (13), (5), (4), (3), (2), (1), (1)
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