Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody

Details for Product No. ABIN250411
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Antigen
Synonyms CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2
Reactivity
Human
(68), (10), (5), (1), (1)
Host
Goat
(40), (31), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(48), (23), (22), (15), (14), (10), (10), (6), (4), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN250411
Quantity 0.1 mg
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Immunogen Synthetic peptide with sequence C-PDALEEPDDQNRI, representing the C Terminus ofthe human protein according to NP_003992.3, NP_001002273.1, NP_001002274.1,NP_001002275.1,. Reference Sequence: NP_003992.3, NP_001002273.1, NP_001002274.1, NP_001002275.1,.
Isotype IgG
Specificity This antibody is expected to recognize all four reported isoforms of CD32(NP_001002273, NP_001002274, NP_001002275, NP_003992). Species Reactivity: Human.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name CD32 / FcRII-a
Background CD32 is a receptor for the Fc region of complexed or aggregated immunoglobulinsgamma. This is a low affinity receptor. It is Involved in a variety of effector andregulatory functions such as phagocytosis of immune complexes and modulation ofantibody production by B-cells. Binding to this receptor results in downmodulation ofprevious state of cell activation triggered via antigen receptors on B cells (BCR), T cells(TCR) or via another Fc receptor. Alternate Names: anti-FCGR2B antibody, anti-CD32 antibody, anti-FCG2 antibody, anti-FCGR2 antibody,anti-IGFR2 antibody, anti-Fc fragment of IgG antibody, anti-low affinity IIb antibody,anti-receptor for (CD32) antibody, anti-Fc gamma RIIb antibody, anti-Fc fragment of IgGantibody, anti-low affinity II antibody, anti-receptor for (CD32) antibody.
Gene ID 2213
NCBI Accession NP_0039923
Application Notes Positive Controls: K562 lysate
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline containing 0.02% sodium azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody Western Blot: CD32 Antibody [ABIN250411] - ABIN250411 (0.3ug/ml) staining of K562 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General McGaha, Sorrentino, Ravetch: "Restoration of tolerance in lupus by targeted inhibitory receptor expression." in: Science (New York, N.Y.), Vol. 307, Issue 5709, pp. 590-3, 2005 (PubMed).

Cappuzzo, Toschi, Tallini et al.: "Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 17, Issue 7, pp. 1120-7, 2006 (PubMed).

Hosts (40), (31), (1)
Reactivities (68), (10), (5), (1), (1)
Applications (48), (23), (22), (15), (14), (10), (10), (6), (4), (1), (1), (1), (1)
Conjugates (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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