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Reticulon 4 Receptor (RTN4R) (Internal Region) antibody

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Synonyms NgR, NGR, NOGOR, NgR1, Nogor
Internal Region
(12), (7), (4), (2), (2), (1), (1), (1), (1), (1), (1)
(45), (22), (13), (3), (2), (1), (1)
(32), (16), (4), (3)
(7), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), ELISA
(46), (21), (8), (2), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Synthetic peptide with sequence C-LQALPDDTFRDLGN, representing the internal region of the human protein according to NP_075380.
Isotype IgG
Cross-Reactivity (Details) Expected cross reactivity from sequence similarity: Mouse, Rat, Pig,Dog.
Purification affinity purified
Alternative Name Nogo 66 receptor (RTN4R Antibody Abstract)
Background This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein andmyelin-associated glycoprotein. This receptor mediates axonal growth inhibition andmay play a role in regulating axonal regeneration and plasticity in the adult centralnervous system. Alternate Names: anti-RTN4R antibody, anti-reticulon 4 receptor antibody, anti-HGNC antibody, anti-1860antibody, anti-NGR antibody, anti-NOGOR antibody, anti-Nogo-66 receptor antibody,anti-UNQ330/PRO526 antibody, anti-nogo receptor antibody, anti-reticulon 4 receptorprecursor antibody.
Gene Symbol: RTN4R
Gene ID 65078
NCBI Accession NP_075380
Pathways Neurotrophin Signaling Pathway
Application Notes Experiments gave bands at approx 90-100kDa and 37+40+45kDa in Human brain lysate after antibody staining. These bands were successfully blocked by the immunizing peptide and they correspond to earlier findings in the literature with different antibodies (Wang et al, J Neurosci. 2002 Jul 1,22(13):5505-15). This protein has a calculated MW of 50.7kDa according to NP_075380.1.
Recommended dilutions: Peptide ELISA detection limit 1:16000, Western Blot 1:100-1:2000
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 with 0.5 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Reticulon 4 Receptor (RTN4R) (Internal Region) antibody (ABIN250419) Western Blot: Nogo 66 receptor Antibody [ABIN250419] - ABIN250419 (0.3ug/ml) staining...
Product cited in: Shao, Browning, Lee et al.: "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration." in: Neuron, Vol. 45, Issue 3, pp. 353-9, 2005 (PubMed).

Catalog No. ABIN250419
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