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Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (AA 4-21), (N-Term) antibody

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N-Term, AA 4-21
(30), (25), (13), (13), (10), (7), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(103), (67), (42), (7), (3), (3), (3), (3), (2), (1)
(144), (11), (8), (7), (1), (1)
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
(110), (99), (33), (17), (13), (11), (8), (8), (6), (3), (2)
Pubmed 5 references available
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Quantity 50 μL
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Immunogen Synthetic peptide: RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.
Isotype IgG
Specificity Vanilloid Receptor 1
Cross-Reactivity Rat (Rattus)
Cross-Reactivity (Details) Not yet tested in other species. May react with Guinea Pig.
Purification Whole antisera
Alternative Name TRPV1 / Vanilloid receptor 1 (TRPV1 Antibody Abstract)
Background Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation ofburning pain by selectively activating sensory neurons that convey information aboutnoxious stimuli to the central nervous system. The protein encoded by this gene is areceptor for capsaicin and is a non-selective cation channel that is structurally related tomembers of the TRP family of ion channels. This receptor is also activated by increasesin temperature in the noxious range, suggesting that it functions as a transducer ofpainful thermal stimuli in vivo. Four transcript variants encoding the same protein, butwith different 5' UTR sequence, have been described for this gene. Alternate Names: anti-capsaicin receptor antibody, anti-DKFZp434K0220 antibody, anti-osm 9 like TRPchannel 1 antibody, anti-OTRPC1 antibody, anti-TRPV1 antibody, anti-Vanilloid receptorsubtype 1 antibody, anti-VR1 antibody.
Gene Symbol: TRPV1
Gene ID 7442
Research Area Receptors, Signaling
Application Notes Immunohistochemistry and Immunocytochemistry 1:1000. Dilution listed only as a recommendation. Optimal dilution should be determined by investigator.
Recommended dilutions: Immunohistochemistry-Frozen 1:10-1:2000, Western Blot 1:100-1:2000, Immunoprecipitation 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry 1:10-1:2000
Restrictions For Research Use only
Format Liquid
Buffer Whole Serum, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Supplier Images
Immunofluorescence (IF) image for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (AA 4-21), (N-Term) antibody (ABIN250444) anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (AA 4-21), (N-Term) antibody
General Sappington, Sidorova, Long et al.: "TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 50, Issue 2, pp. 717-28, 2009 (PubMed).

Sappington, Calkins: "Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 49, Issue 7, pp. 3004-17, 2008 (PubMed).

Stein, Ufret-Vincenty, Hua et al.: "Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane." in: The Journal of general physiology, Vol. 128, Issue 5, pp. 509-22, 2006 (PubMed).

Guo, Vulchanova, Wang et al.: "Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites." in: The European journal of neuroscience, Vol. 11, Issue 3, pp. 946-58, 1999 (PubMed).

Caterina, Schumacher, Tominaga et al.: "The capsaicin receptor: a heat-activated ion channel in the pain pathway." in: Nature, Vol. 389, Issue 6653, pp. 816-24, 1997 (PubMed).

Catalog No. ABIN250444

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