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Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) antibody

Antigen

Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1)
Synonyms VR1, DKFZp434K0220, Vr1, Vr1l1, VR.5'sv, VR-1, OTRPC1, TRPV1beta, TRPV1alpha, TRPV1, Trpv1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Monkey, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
5 references available
Catalog no. ABIN250444
Quantity 50 µl  (Variants)
Price Product not available in this region.
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anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) antibody

Additional Information
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Alternative name TRPV1 / Vanilloid receptor 1
Immunogen Synthetic peptide: RASLDSEESESPPQENSC, corresponding to amino-terminus of RatVR1, amino acids 4-21.
Format Serum
Isotype IgG
Description Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation ofburning pain by selectively activating sensory neurons that convey information aboutnoxious stimuli to the central nervous system. The protein encoded by this gene is areceptor for capsaicin and is a non-selective cation channel that is structurally related tomembers of the TRP family of ion channels. This receptor is also activated by increasesin temperature in the noxious range, suggesting that it functions as a transducer ofpainful thermal stimuli in vivo. Four transcript variants encoding the same protein, butwith different 5' UTR sequence, have been described for this gene. Alternate Names: anti-capsaicin receptor antibody, anti-DKFZp434K0220 antibody, anti-osm 9 like TRPchannel 1 antibody, anti-OTRPC1 antibody, anti-TRPV1 antibody, anti-Vanilloid receptorsubtype 1 antibody, anti-VR1 antibody.
Specificity Species Reactivity: Cross-reacts with Mouse, Rat and Non Human Primates. Not yet tested in otherspecies. Localization: Plasma membrane.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1/1000 ,Immunocytochemistry 1/1000,Immunohistochemistry-Frozen 1/1000. Positive Controls: VR1 transfected cells.
Buffer Whole Serum. Preservative: 0.05% sodium azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Research Area Receptors, Signaling
Restrictions For Research Use only

Publications
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Caterina, Schumacher, Tominaga et al.: "The capsaicin receptor: a heat-activated ion channel in the pain pathway." in: Nature, Vol. 389, Issue 6653, pp. 816-24, 1997 (PubMed).

Guo, Vulchanova, Wang et al.: "Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites." in: The European journal of neuroscience, Vol. 11, Issue 3, pp. 946-58, 1999 (PubMed).

Stein, Ufret-Vincenty, Hua et al.: "Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane." in: The Journal of general physiology, Vol. 128, Issue 5, pp. 509-22, 2006 (PubMed).

Sappington, Calkins: "Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 49, Issue 7, pp. 3004-17, 2008 (PubMed).

Sappington, Sidorova, Long et al.: "TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 50, Issue 2, pp. 717-28, 2009 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1)", type "Antibodies"
Hosts Rabbit (83), Sheep (7), Mouse (6), Guinea Pig (3), Goat (2)
Reactivities Human (49), Rat (Rattus) (49), Mouse (Murine) (29), Dog (Canine) (18), Guinea Pig (18), Pig (Porcine) (18), Rabbit (3), Zebrafish (Danio rerio) (3), Chicken (1), Crocodile (1), Monkey (1)
Applications Western Blotting (WB) (62), Immunohistochemistry (IHC) (56), Immunofluorescence (IF) (24), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunohistochemistry (Fixed) (IHC (fx)) (13), ELISA (12), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunostaining (ISt) (3), Immunocytochemistry (ICC) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (11), 4th Cytoplasmic Loop (10), 1st Cytoplasmic Loop (8), N-Term (5), 3rd Extracellular Loop (4), 1st Cytoplasmic Domain (3), pThr145 (3), 1st Extracellular Loop (2), 4th Cytoplasmic Domain (2), 2nd Cytoplasmic Loop (1), 3rd Cytoplasmic Loop (1), AA 105-115 (1), AA 531-541 (1), AA 608-621 (1), AA 7-21 (1), AA 819-838 (1), Internal Region (1)