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TRPV1 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 1)

Details for Product anti-TRPV1 Antibody No. ABIN250444, Supplier: Log in to see
Antigen
  • si:dkey-9e15.2
  • VR.5'sv
  • Vr1
  • Vr1l1
  • VR1
  • OTRPC1
  • TRPV1alpha
  • TRPV1beta
  • VR-1
  • transient receptor potential cation channel, subfamily V, member 1
  • trpv1
  • Trpv1
  • TRPV1
Reactivity
Human, Primate, Rat (Rattus)
95
71
45
10
3
2
2
2
2
1
1
1
Host
Rabbit
123
11
8
5
1
1
Clonality
Polyclonal
Conjugate
This TRPV1 antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
92
91
24
14
13
10
8
8
5
3
2
Options
Supplier
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Immunogen Synthetic peptide: RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.
Specificity Vanilloid Receptor 1
Purification Unpurified
Alternative Name TRPV1 / Vanilloid receptor 1 (TRPV1 Antibody Abstract)
Background Gene Symbol: TRPV1
Gene ID 7442
UniProt O35433
Application Notes Western Blot 1:100-1:2000, Immunohistochemistry 1:1000, Immunocytochemistry/Immunofluorescence 1:1000, Immunoprecipitation, Immunohistochemistry-Paraffin 1:1000, Immunohistochemistry-FrozenImmunohistochemistry and Immunocytochemistry 1:1000. Dilution listed only as a recommendation. Optimal dilution should be determined by investigator. IHC-Frozen reactivity reported in scientific literature (PMID: 23573230), Immunoprecipitation reactivity reported in scientific literature (PMID: 25801060)
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer Whole antisera
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage -80 °C,-20 °C
Storage Comment Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Supplier Images
Immunofluorescence (IF) image for anti-TRPV1 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 1) (ABIN250444) anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) antibody
Immunofluorescence (IF) image for anti-TRPV1 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 1) (ABIN250444) Immunocytochemistry/Immunofluorescence: Vanilloid R1/TRPV1 Antibody [ABIN250444] - TR...
Product cited in: Sappington, Sidorova, Ward, Chakravarthy, Ho, Calkins: "Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress." in: Channels (Austin, Tex.), Vol. 9, Issue 2, pp. 102-13, 2015 (PubMed). Further details: Western Blotting

Huang, Yu, Sanchez, Liu, Min, Hu, Bsoul, Han, Yin, Liu, He, Peng: "TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain." in: Brain, behavior, and immunity, Vol. 48, pp. 68-77, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunoprecipitation

Zhao, Fan, Higgins, Qi, Haines, Trivett, Oppenheim, Wei, Li, Lin, Howard: "Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways." in: Cancer letters, Vol. 355, Issue 2, pp. 232-41, 2014 (PubMed).

Starowicz, Makuch, Korostynski, Malek, Slezak, Zychowska, Petrosino, De Petrocellis, Cristino, Przewlocka, Di Marzo: "Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism." in: PLoS ONE, Vol. 8, Issue 4, pp. e60040, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen Sections)

Sappington, Sidorova, Long, Calkins: "TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 50, Issue 2, pp. 717-28, 2009 (PubMed).

Sappington, Calkins: "Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 49, Issue 7, pp. 3004-17, 2008 (PubMed).

Stein, Ufret-Vincenty, Hua, Santana, Gordon: "Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane." in: The Journal of general physiology, Vol. 128, Issue 5, pp. 509-22, 2006 (PubMed).

Aoki, Ohtori, Takahashi, Ino, Douya, Ozawa, Saito, Moriya: "Expression and co-expression of VR1, CGRP, and IB4-binding glycoprotein in dorsal root ganglion neurons in rats: differences between the disc afferents and the cutaneous afferents." in: Spine, Vol. 30, Issue 13, pp. 1496-500, 2005 (PubMed).

Liapi, Wood: "Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex." in: The European journal of neuroscience, Vol. 22, Issue 4, pp. 825-34, 2005 (PubMed).

Sharif Naeini, Witty, Séguéla, Bourque: "An N-terminal variant of Trpv1 channel is required for osmosensory transduction." in: Nature neuroscience, Vol. 9, Issue 1, pp. 93-8, 2005 (PubMed).

Zimov, Yazulla: "Localization of vanilloid receptor 1 (TRPV1/VR1)-like immunoreactivity in goldfish and zebrafish retinas: restriction to photoreceptor synaptic ribbons." in: Journal of neurocytology, Vol. 33, Issue 4, pp. 441-52, 2004 (PubMed).

Rosenbaum, Awaya, Gordon: "Subunit modification and association in VR1 ion channels." in: BMC neuroscience, Vol. 3, pp. 4, 2003 (PubMed).

Labrakakis, Tong, Weissman, Torsney, MacDermott: "Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat." in: The Journal of physiology, Vol. 549, Issue Pt 1, pp. 131-42, 2003 (PubMed).

Nakatsuka, Tsuzuki, Ling, Sonobe, Gu: "Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord." in: Journal of neurophysiology, Vol. 89, Issue 6, pp. 3243-52, 2003 (PubMed).

Zahner, Li, Chen, Pan: "Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats." in: The Journal of physiology, Vol. 551, Issue Pt 2, pp. 515-23, 2003 (PubMed).

Reference: Guo, Vulchanova, Wang, Li, Elde: "Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites." in: The European journal of neuroscience, Vol. 11, Issue 3, pp. 946-58, 1999 (PubMed).

Caterina, Schumacher, Tominaga, Rosen, Levine, Julius: "The capsaicin receptor: a heat-activated ion channel in the pain pathway." in: Nature, Vol. 389, Issue 6653, pp. 816-24, 1997 (PubMed).

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