Cathepsin F (CTSF) antibody

Details for Product No. ABIN250491
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Antigen
Synonyms CATSF, CLN13, AI481912, CTSF, MGC140519, cb420, sb:cb420, zgc:153093, LOC100101596, Ctsf, ACYPI000376, catf
Reactivity
Human
(22), (7), (4), (3)
Host
Goat
(16), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1)
Application
Western Blotting (WB), ELISA
(20), (10), (4), (3), (2), (1)
Pubmed 2 references available
Catalog no. ABIN250491
Quantity 0.1 mg
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Immunogen Synthetic peptide: CGVNTMASSAVVD, representing the C Terminus of the humanprotein according to NP_003784.2. Reference Sequence: NP_003784.2.
Isotype IgG
Specificity Species Reactivity: Cross-reacts with Human. Expected to cross-react with Mouse, Dog. Not yet tested inother species.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name Cathepsin F
Background Cathepsins are papain family cysteine proteinases that represent a major component ofthe lysosomal proteolytic system. Cathepsins generally contain a signal sequence,followed by a propeptide and then a catalytically active mature region. The very long(251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminaldomain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexiblelinker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. Thecathepsin F proregion is unique within the papain family cysteine proteases in that itcontains this additional N-terminal segment predicted to share structural similarities withcysteine protease inhibitors of the cystatin superfamily. This cystatin-like domaincontains some of the elements known to be important for inhibitory activity. CTSFencodes a predicted protein of 484 amino acids which contains a 19 residue signalpeptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targetedto the endosomal/lysosomal compartment via the mannose 6-phosphate receptorpathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome11q13, close to the gene encoding cathepsin W. Alternate Names: anti-CTSF antibody, anti-cathepsin F antibody, anti-HGNC antibody, anti-2531 antibody,anti-CATSF antibody.
Gene ID 8722
NCBI Accession NP_0037842
Research Area Immunology, Innate Immunity, Proteases
Application Notes Positive Controls: Human Prostate and Ovary lysates
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris-saline containing 0.02% Na azide (pH7.3) with 0.5% BSA
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Cathepsin F (CTSF) antibody Western Blot: Cathepsin F Antibody [ABIN250491] - ABIN250491 (0.3ug/ml) staining of Human Ovary lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General Dorn, Zhao, Granberg et al.: "Identification of specific cellular genes up-regulated late in adenovirus type 12 infection." in: Journal of virology, Vol. 79, Issue 4, pp. 2404-12, 2005 (PubMed).

Maubach, Lim, Zhuo: "Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells." in: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4238-48, 2008 (PubMed).

Hosts (16), (5), (2)
Reactivities (22), (7), (4), (3)
Applications (20), (10), (4), (3), (2), (1)
Conjugates (1), (1), (1)
Epitopes (3), (2), (2), (1), (1), (1), (1), (1)
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