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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) antibody

Antigen

X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3)
Clonality Monoclonal (10F1-6)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN250516
Quantity 25 µl  (1.3 mg/ml)  (Variants)
Price Product not available in this region.
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) antibody

Additional Information
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Alternative name XRCC3
Gene ID 7517
Immunogen His-tagged human XRCC3, over-expressed in E. coli.
Isotype IgG1  (Matching secondary antibodies)
Clone 10F1-6
Description Five human RAD51 homologs have been identified: XRCC2, XRCC3, RAD51B,RAD51C, and RAD51D. Each of these homologs interacts with one or more of theothers, with all of the proteins involved in one complex or multiple smaller complexes.XRCC3 (x-ray cross complementing) was first identified as a human genecomplementing the DNA damage sensitivity, chromosonal instability and impairedgrowth of the mutant hamster cell line irs1SF. This fact coupled with XRCC3 being amember of the RAD51 gene family have implied a role in the repair of DNA damage byhomologous recombination. Alternate Names: anti-DNA repair protein XRCC3 antibody, anti-X ray repair complementing defectiverepair in Chinese hamster cells 3 antibody, anti-X ray repair cross complementingprotein 3 antibody.
Specificity This antibody is specific for XRCC3. Species Reactivity: Human XRCC3. Does not work in mouse. Other species not tested. ABIN151307 doesnot cross-react with Rad51B, Rad51C, Rad51D, Rad51, or XRCC2 in Western analysis. Localization: Nuclear.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:1000
Concentration 1.3 mg/ml
Buffer Preservative: 0.1% sodium azide.
Storage Store at 4C. Do not freeze.
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Restrictions For Research Use only

Publications
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Publications Forget, Bennett, Knight: "Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51." in: Journal of cellular biochemistry, Vol. 93, Issue 3, pp. 429-36, 2004 (PubMed).

Fan, Kumaravel, Jalali et al.: "Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression." in: Cancer research, Vol. 64, Issue 23, pp. 8526-33, 2004 (PubMed).

Alternatives
Application Details Publications Images Secondary Antibodies Variants back to top

Alternatives for antigen "X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3)", type "Antibodies"
Hosts Rabbit (34), Mouse (4)
Reactivities Human (36), Mouse (Murine) (15)
Applications Western Blotting (WB) (24), Immunofluorescence (IF) (15), Flow Cytometry (FACS) (13), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), ELISA (7), ELISA (Detection) (3), Enzyme Immunoassay (EIA) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (EM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
Epitopes Center (2)