FANCD2 antibody (Fanconi Anemia, Complementation Group D2) (N-Term) (HRP)

Details for Product anti-FANCD2 Antibody No. ABIN250521, Supplier: Log in to see
Antigen
  • FANCD2
  • CG17269
  • CG31192
  • CG31194
  • Dmel\\CG17269
  • dmFANCD2
  • xfancd2
  • FA-D2
  • FA4
  • FACD
  • FAD
  • FAD2
  • FANCD
  • 2410150O07Rik
  • AU015151
  • BB137857
  • Fanconi anemia, complementation group D2
  • CG17269 gene product from transcript CG17269-RA
  • FANCD2
  • Fancd2
  • fancd2
Epitope
N-Term
33
24
15
11
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Primate
144
66
47
11
11
2
1
1
Host
Rabbit
127
17
Clonality
Polyclonal
Conjugate
This FANCD2 antibody is conjugated to HRP
7
6
5
5
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
106
48
39
27
24
24
14
12
10
4
2
1
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen Human FANCD2 fusion protein (N-terminal fragment). [Swiss-Prot #Q9BXW9]
Specificity This antibody is specific for FANCD2.
Purification Immunogen affinity purified
Alternative Name FANCD2 (FANCD2 Antibody Abstract)
Background Gene Symbol: FANCD2
Gene ID 2177
UniProt Q9BXW9
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Western Blot, Immunohistochemistry, Immunohistochemistry-ParaffinBy Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights. For immunofluorescence it has been tested in human MMC and IR treated MEF cells. This antibody may also be used for Immunoprecipitation and Immunohistochemistry-Paraffin
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: No Preservative
Preservative Without preservative
Storage 4 °C
Storage Comment Store at 4°C in the dark.
Supplier Images
Immunofluorescence (IF) image for anti-FANCD2 antibody (Fanconi Anemia, Complementation Group D2) (N-Term) (HRP) (ABIN250521) FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to ...
Immunofluorescence (IF) image for anti-FANCD2 antibody (Fanconi Anemia, Complementation Group D2) (N-Term) (HRP) (ABIN250521) FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to ...
Western Blotting (WB) image for anti-FANCD2 antibody (Fanconi Anemia, Complementation Group D2) (N-Term) (HRP) (ABIN250521) FANCD2 in HeLa WCE using ABIN151329 (lot C).
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-FANCD2 antibody (Fanconi Anemia, Complementation Group D2) (N-Term) (HRP) (ABIN250521) Immunohistochemistry-Paraffin: FANCD2 Antibody [HRP] [ABIN250521H] - Staining of huma...
Product cited in: Oda, Hayano, Miyaso, Takahashi, Yamashita: "Hsp90 regulates the Fanconi anemia DNA damage response pathway." in: Blood, Vol. 109, Issue 11, pp. 5016-26, 2007 (PubMed).

Jacquemont, Taniguchi: "Proteasome function is required for DNA damage response and fanconi anemia pathway activation." in: Cancer research, Vol. 67, Issue 15, pp. 7395-405, 2007 (PubMed).

Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, 2006 (PubMed).

Mukhopadhyay, Leung, Hicks, Hastings, Youssoufian, Plon: "Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia." in: The Journal of cell biology, Vol. 175, Issue 2, pp. 225-35, 2006 (PubMed).

Dunn, Potter, Rees, Rünger: "Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light." in: Cancer research, Vol. 66, Issue 23, pp. 11140-7, 2006 (PubMed).

Donahue, Campbell: "A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts." in: Nucleic acids research, Vol. 32, Issue 10, pp. 3248-57, 2004 (PubMed).

Rothfuss, Grompe: "Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway." in: Molecular and cellular biology, Vol. 24, Issue 1, pp. 123-34, 2003 (PubMed).

Taniguchi, Tischkowitz, Ameziane, Hodgson, Mathew, Joenje, Mok, DAndrea: "Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors." in: Nature medicine, Vol. 9, Issue 5, pp. 568-74, 2003 (PubMed).

Digweed, Rothe, Demuth, Scholz, Schindler, Stumm, Grompe, Jordan, Sperling: "Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia." in: Carcinogenesis, Vol. 23, Issue 7, pp. 1121-6, 2002 (PubMed).

Taniguchi, Garcia-Higuera, Andreassen, Gregory, Grompe, DAndrea: "S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51." in: Blood, Vol. 100, Issue 7, pp. 2414-20, 2002 (PubMed).

Background publications Sridharan, Brown, Lambert, McMahon, Lambert: "Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links." in: Journal of cell science, Vol. 116, Issue Pt 5, pp. 823-35, 2003 (PubMed).

Lensch, Tischkowitz, Christianson, Reifsteck, Speckhart, Jakobs, ODwyer, Olson, Le Beau, Hodgson, Mathew, Larson, Bagby: "Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia." in: Blood, Vol. 102, Issue 1, pp. 7-16, 2003 (PubMed).

Olopade, Wei: "FANCF methylation contributes to chemoselectivity in ovarian cancer." in: Cancer cell, Vol. 3, Issue 5, pp. 417-20, 2003 (PubMed).

Garcia-Higuera, Taniguchi, Ganesan, Meyn, Timmers, Hejna, Grompe, DAndrea: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

McMahon, Sangerman, Goodman, Kumaresan, Lambert: "Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links." in: Biochemistry, Vol. 40, Issue 24, pp. 7025-34, 2001 (PubMed).