Wolfram Syndrome 1 (WFS1) (N-Term) antibody

Details for Product No. ABIN250566
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Synonyms CG4917, Dmel\\CG4917, GB15257, WFS1, WFRS, WFS, WFSL, AI481085, wolframin
(3), (3), (3), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(27), (22), (21)
(30), (1)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(21), (12), (10), (5), (4), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 25 μL
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Catalog No. ABIN250566
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Immunogen A 110 amino acid sequence from the N-terminal region of the human WFS1 protein.
Purification Whole antisera
Alternative Name Wolframin / WFS1
Background WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum(ER) in the pancreas. It is normally up-regulated during insulin secretion, whereasinactivation of the protein can cause ER stress. Chronic ER stress is a majorinvolvement in Wolfram syndrome. Alternate Names: anti-Wolfram antibody, anti-wolfram syndrome 1 antibody. Related Diseases: Diabetes, Wolfram Syndrome, Neurodegenerative Disease
Gene Symbol: WFS1
Gene ID 7466
UniProt O76024
Application Notes This WFS1 antibody is useful for Immunofluorescence/Immunocytochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation and Western Blot. In WB bands are observed at ~100 kDa and ~200 kDa representing the monomer and dimer forms of WFS1.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:200, Immunohistochemistry 1:1000, Immunohistochemistry-Frozen 1:1000, Immunohistochemistry-Paraffin 1:1000, Immunoprecipitation 2 µL, Western Blot 1:500-1:2000
Restrictions For Research Use only
Format Liquid
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Supplier Images
anti-Wolfram Syndrome 1 (WFS1) (N-Term) antibody Detection of WFS1 in insulinoma cells in WB using ABIN151416.
anti-Wolfram Syndrome 1 (WFS1) (N-Term) antibody (2) Immunoprecipitation of WFS1 using ABIN151416. Precipitated lysate is INS-1.
General Fonseca, Fukuma, Lipson et al.: "WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39609-15, 2005 (PubMed).

Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

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