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Details for Product No. ABIN250566

Wolfram Syndrome 1 (WFS1) antibody

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Antigen
Synonyms CG4917, Dmel\\CG4917, GB15257, WFS1
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN250566
Quantity 25 µL
Price
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Immunogen A 110 amino acid region of the N-terminal region of thehuman protein.
Specificity Species Reactivity: ABIN151416 can be used to detect human, rat and mouse WFS1 protein. Localization: Endoplasmic reticulum.
Purification Serum
Alternative Name Wolframin / WFS1
Background WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum(ER) in the pancreas. It is normally up-regulated during insulin secretion, whereasinactivation of the protein can cause ER stress. Chronic ER stress is a majorinvolvement in Wolfram syndrome. Alternate Names: anti-Wolfram antibody, anti-wolfram syndrome 1 antibody. Related Diseases: Diabetes, Wolfram Syndrome, Neurodegenerative Disease
Gene ID 7466
Application Notes Suggested working dilutions: immunofluorescence 1:200,immunoprecipitation 2 ul,Western Blot 1:500-1:2000,Immunohistochemistry-Frozen 1:1000. Positive Controls: See notes.
Restrictions For Research Use only
Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Fonseca, Fukuma, Lipson et al.: "WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39609-15, 2005 (PubMed).

Alternatives for antigen "Wolfram Syndrome 1 (WFS1)", type "Antibodies"
Hosts (23), (2)
Reactivities (23), (23), (22), (12), (12)
Applications (15), (10), (7), (6), (5), (4), (4), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (1), (1)
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