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Details for Product No. ABIN250711

Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) antibody

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Synonyms 9030414B18Rik, AI225830, C85377, Ire1a, Ire1alpha, Ire1p, RGD1559716, IRE1, IRE1P, IRE1a, hIRE1p
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN250711
Quantity 0.1 mL
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Immunogen A synthetic peptide within the human IRE1 alpha protein (within residues 700-800). [Swiss-Prot #O75460].
Specificity Species Reactivity: Reacts with human, mouse, and rat. Does not react with monkey. Localization: Endoplasmic reticulum.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Aff - Purified
Alternative Name ERN1 / IRE1
Background IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of theunfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting itinto a potent unfolded-protein response transcriptional activator. It is a transmembraneprotein that has both serine-threonine kinase and endoribonuclease activities. Nullmutants are viable, but IRE1 is essential for viability under stress conditions that causeunfolded proteins to accumulate in the ER. Alternate Names: anti-Serine/threonine-protein kinase/endoribonuclease IRE1 antibody,anti-Inositol-requiring protein 1 antibody, anti-IRE1p antibody, anti-IRE1a antibody,anti-Ire1-alpha antibody, anti-ERN1 antibody, anti-Endoplasmic reticulum-to-nucleussignaling 1 antibody. Related Diseases: Neurodegenerative Disease, Cancer
Gene ID 2081, 78943, 498013
UniProt O75460
Application Notes Suggested working dilutions: Western Blot 1:1000-1:2000. Positive Controls: Pancreatic islets and insulinoma cells.
Restrictions For Research Use only
Concentration 0.2 mg/ml
Buffer PBS. Preservative: No preservative.
Storage -20 °C
Kubota, Lee, Tsuchiya et al.: "Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation." in: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 23194-202, 2005 (PubMed).

Fonseca, Fukuma, Lipson et al.: "WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39609-15, 2005 (PubMed).

Lipson, Fonseca, Ishigaki et al.: "Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1." in: Cell metabolism, Vol. 4, Issue 3, pp. 245-54, 2006 (PubMed).

Luo, He, Zhang et al.: "AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 11905-12, 2008 (PubMed).

Alternatives for antigen "Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1)", type "Antibodies"
Hosts (93), (21), (9)
Reactivities (112), (51), (48), (26), (24), (24)
Applications (102), (56), (21), (20), (16), (9), (5), (2), (1), (1)
Conjugates (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (20), (12), (10), (9), (8), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1)