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Details for Product No. ABIN250774

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

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Antigen
Synonyms FLK1, CD309, VEGFR, VEGFR2, Vegfr-2, FLK-1, flk-1, FLK/KDR, vegfr-2, KDR
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN250774
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide made to a C-terminal region of the murine VEGFR2 proteinsequence (between residues 1300-1367). [Swiss-Prot# P35918].
Specificity This antibody has only been shown to recognize the native form (180-190 kDa protein)of VEGFR-2, known as Flk-1 / KDR / VEGFR 2 (Vascular Endothelial Growth FactorReceptor 2), though it was raised against the precursor form. It has not beencharacterized against the other forms of VEGFR-2. It has not been tested forcross-reactivity with VEGFR-1. Species Reactivity: This antibody reacts with human protein. Other species have not yet been tested. Thisantibody has a high likelihood of also reacting with mouse and rat proteins. Localization: Type I membrane protein.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name CD309 / VEGFR-2 / Flk-1
Background Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. TheVEGF-kinase ligand/receptor signaling system plays a key role in vascular developmentand regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, arethought to be important for the development of embryonic vasculature. It has beenshown that an alternately spliced form of FLT1 produces a soluble protein, termedsFLT1, which binds vascular endothelial growth factor with high affinity, playing aninhibitory role in angiogenesis. Alternate Names: anti-VEGFR-2 antibody, anti-VEGFR 2 antibody, anti-Protein-tyrosine kinase receptorflk-1 antibody, anti-Fetal liver kinase 1 antibody, anti-Kinase NYK antibody, anti-FLK1antibody, anti-KDR antibody, anti-Kinase insert domain receptor antibody, anti-KRD1antibody, anti-Ly73 antibody, anti-Protein tyrosine kinase receptor FLK1 antibody,anti-Vascular endothelial growth factor receptor 2 antibody.
Gene ID 3791
Research Area Cytokines, Receptors
Application Notes Suggested working dilutions: Western Blot 1 ug/ml
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate buffer, pH 7-8. Preservative: 0.1% sodium azide
Preservative Sodium azide
Storage 4 °C
Rahimi, Dayanir, Lashkari: "Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16986-92, 2000 (PubMed).

Gluzman-Poltorak, Cohen, Shibuya et al.: "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 18688-94, 2001 (PubMed).

Takahashi, Hattori, Iwamatsu et al.: "A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46304-14, 2004 (PubMed).

Hu-Lowe, Zou, Grazzini et al.: "Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 22, pp. 7272-83, 2008 (PubMed).

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts (377), (78), (36), (3), (3), (2)
Reactivities (417), (260), (158), (18), (17), (14), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Applications (354), (157), (136), (122), (81), (77), (40), (38), (24), (20), (8), (7), (4), (4), (2), (2), (1)
Conjugates (35), (6), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (46), (39), (39), (26), (19), (16), (12), (11), (10), (7), (7), (6), (6), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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