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Details for Product No. ABIN251103

DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) antibody

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Antigen
Synonyms DNMT3A2, M.HsaIIIA, DNMT3A
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN251103
Quantity 25 µL
Price
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Immunogen This antibody was raised against amino acids 10-118 ofthe human DNMT3a protein.
Specificity This antibody is specific for the DNMT3a protein. Species Reactivity: ABIN151733 recognizes human. Other species have notbeen tested.
Cross-Reactivity Human
Alternative Name DNMT3A
Background Inactivation of tumor suppressor genes is a key component of the development of allcommon forms of human cancers. Aberrant methylation may contribute to many of thechanges, both physiological and pathological, associated with aging, including tumordevelopment. Hypermethylation of CpG island-containing promoters is associated withthe inactivation of genes important to tumor angiogenesis and progression. DNAmethytransferase (DNMT3a) is necessary for the maintenance of the methylationprocess. Alternate Names: anti-DNMT3A2 antibody, anti-M.HsaIIIA antibody.
Gene ID 1788
Application Notes Positive Controls: HCT116 cell lysates
Restrictions For Research Use only
Beaulieu, Morin, Chute et al.: "An essential role for DNA methyltransferase DNMT3B in cancer cell survival." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28176-81, 2002 (PubMed).

Weisenberger, Velicescu, Preciado-Lopez et al.: "Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells." in: Gene, Vol. 298, Issue 1, pp. 91-9, 2002 (PubMed).

Robert, Morin, Beaulieu et al.: "DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells." in: Nature genetics, Vol. 33, Issue 1, pp. 61-5, 2003 (PubMed).

Reynolds, Sigaroudinia, Zardo et al.: "Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24790-802, 2006 (PubMed).

Shikauchi, Saiura, Kubo et al.: "SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma." in: Molecular and cellular biology, Vol. 29, Issue 7, pp. 1944-58, 2009 (PubMed).

Alternatives for antigen "DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A)", type "Antibodies"
Hosts (73), (15), (3), (2)
Reactivities (87), (34), (22), (15), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (78), (29), (18), (15), (10), (10), (8), (6), (3), (3)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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