Egl Nine Homolog 3 (C. Elegans) (EGLN3) antibody

Details for Product No. ABIN251418
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Antigen
Synonyms HIFP4H3, HIFPH3, PHD3, 2610021G09Rik, AI505553, AI648162, Hif-p4h-3, Phd3, SM-20, phd3, PHD-3, zgc:77019, wu:fj78a08, EGLN3
Reactivity
Human
(51), (23), (23), (17), (14), (13), (6), (1), (1)
Host
Rabbit
(36), (14), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (12), (10), (10), (5), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN251418
Quantity 25 µL
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Specificity This antibody is specific for HIF prolyl hydroxylase 3. Species Reactivity: Cross reacts with Human and Mouse.
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name EGLN3 / PHD3
Background PHD3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-induciblefactor (HIF) alpha proteins, hydroxylates HIF-1 alpha at Pro-564, and also hydroxylatesHIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions,targets HIF through the hydroxylation for proteasomal degradation via the vonHippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation inmuscle cells and in apoptosis in neuronal tissue. It promotes cell death through acaspase-dependent mechanism. Alternate Names: anti-EGL9 homolog of C. elegans 3 antibody, anti-EGLN3 antibody, anti-Factorresponsive smooth muscle protein antibody, anti-HIF Prolyl Hydroxylase 3 antibody,anti-HIFP4H3 antibody, anti-HIFPH3 antibody, anti-P4H3 antibody, anti-ProlylHydroxylase Domain Containing Protein 3 antibody, anti-SM20 antibody.
Gene ID 112399
Application Notes Suggested working dilutions: Western Blot 1:1000-1:3000
Restrictions For Research Use only
Format Liquid
Concentration 1.0mg/ml
Buffer Tris-citrate/phosphate [pH 7-8]. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Egl Nine Homolog 3 (C. Elegans) (EGLN3) antibody Western Blot: PHD3 Antibody [ABIN151769SS] - Western Blot analysis of human PHD3, using ABIN151769. Samples: HeLa whole cell lysates and MEFs.
General Ietta, Wu, Winter et al.: "Dynamic HIF1A regulation during human placental development." in: Biology of reproduction, Vol. 75, Issue 1, pp. 112-21, 2006 (PubMed).

Takeda, Aguila, Parikh et al.: "Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins." in: Blood, Vol. 111, Issue 6, pp. 3229-35, 2008 (PubMed).

Minamishima, Moslehi, Bardeesy et al.: "Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure." in: Blood, Vol. 111, Issue 6, pp. 3236-44, 2008 (PubMed).

Hosts (36), (14), (5)
Reactivities (51), (23), (23), (17), (14), (13), (6), (1), (1)
Applications (43), (12), (10), (10), (5), (2), (1), (1), (1)
Conjugates (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (3), (2), (1), (1), (1), (1)
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