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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody
|Synonyms||p202, 53BP1, FLJ41424, MGC138366, Trp53bp1, TP53BP1, MGC160112|
Alternatives Immunofluorescence (IF), Western Blotting (WB)
|8 references available|
|Quantity||25 µl (1 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Immunogen||A synthetic peptide, which represented a portion of human tumor protein p53 bindingprotein 1 encoded exon 19 (LocusLink ID 7158).|
|Cross-Reactivity||Human, Mouse (Murine)|
|Description||P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.|
|Specificity||ABIN151771 is specific for human 53BP1 protein. Species Reactivity: Human in Western Blot andimmunocytochemistry/immunofluorescence and it reactswith Mouse in immunocytochemistry/immunofluorescence (Western Blot has not beendone using this antibody on Mouse protein). Localization: Nuclear. Associated with kinetochores. Both nuclear and cytoplasmic in some cells.|
|Application Notes||Suggested working dilutions: immunofluorescence 1:200-1:1000,Western Blot 1:2000-1:10000,Immunocytochemistry 1:200-1:1000. Positive Controls: U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse)|
|Purification||Aff - Purified|
|Buffer||PBS. Preservative: 0.09% Sodium Azide.|
|Storage||Store at 4C. Do not freeze.|
|Research Area||Transcription Factors|
|Restrictions||For Research Use only|
Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).
Rothkamm, Balroop, Shekhdar et al.: "Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure." in: Radiology, Vol. 242, Issue 1, pp. 244-51, 2006 (PubMed).
Ibarra, Schwob, Muendez: "Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 26, pp. 8956-61, 2008 (PubMed).
Guirouilh-Barbat, Redon, Pommier: "Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex." in: Molecular biology of the cell, Vol. 19, Issue 9, pp. 3969-81, 2008 (PubMed).
Wirthner, Wrann, Balamurugan et al.: "Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts." in: Carcinogenesis, Vol. 29, Issue 12, pp. 2306-16, 2008 (PubMed).
Palm, Hockemeyer, Kibe et al.: "Functional dissection of human and mouse POT1 proteins." in: Molecular and cellular biology, Vol. 29, Issue 2, pp. 471-82, 2008 (PubMed).
Solier, Sordet, Kohn et al.: "Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 68-82, 2008 (PubMed).
Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).