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Details for Product No. ABIN251421

Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

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Antigen
Synonyms 53BP1, p202, Trp53bp1, Tp53bp1, m53BP1, TP53BP1, MGC160112
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN251421
Quantity 25 µL
Price
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Immunogen A synthetic peptide, which represented a portion of human tumor protein p53 bindingprotein 1 encoded exon 19 (LocusLink ID 7158).
Specificity ABIN151771 is specific for human 53BP1 protein. Species Reactivity: Human in Western Blot andimmunocytochemistry/immunofluorescence and it reactswith Mouse in immunocytochemistry/immunofluorescence (Western Blot has not beendone using this antibody on Mouse protein). Localization: Nuclear. Associated with kinetochores. Both nuclear and cytoplasmic in some cells.
Cross-Reactivity Human, Mouse (Murine)
Purification Affinity Purified
Alternative Name TP53BP1
Background P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.
Gene ID 7158
Research Area Transcription Factors
Application Notes Suggested working dilutions: immunofluorescence 1:200-1:1000,Western Blot 1:2000-1:10000,Immunocytochemistry 1:200-1:1000. Positive Controls: U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse)
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer PBS. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).

Rothkamm, Balroop, Shekhdar et al.: "Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure." in: Radiology, Vol. 242, Issue 1, pp. 244-51, 2006 (PubMed).

Ibarra, Schwob, Muendez: "Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 26, pp. 8956-61, 2008 (PubMed).

Guirouilh-Barbat, Redon, Pommier: "Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex." in: Molecular biology of the cell, Vol. 19, Issue 9, pp. 3969-81, 2008 (PubMed).

Wirthner, Wrann, Balamurugan et al.: "Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts." in: Carcinogenesis, Vol. 29, Issue 12, pp. 2306-16, 2008 (PubMed).

Palm, Hockemeyer, Kibe et al.: "Functional dissection of human and mouse POT1 proteins." in: Molecular and cellular biology, Vol. 29, Issue 2, pp. 471-82, 2008 (PubMed).

Solier, Sordet, Kohn et al.: "Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 68-82, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts (115), (10), (1)
Reactivities (123), (78), (42), (36), (12), (12)
Applications (86), (42), (32), (30), (29), (22), (20), (16), (4), (2)
Conjugates (8), (8), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (17), (13), (12), (10), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)
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