Add to Basket
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

Antigen

Tumor Protein P53 Binding Protein 1 (TP53BP1)
Synonyms p202, 53BP1, FLJ41424, MGC138366, Trp53bp1, TP53BP1, MGC160112
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunofluorescence (IF), Western Blotting (WB)
8 references available
Catalog no. ABIN251421
Quantity 25 µl  (1 mg/ml)  (Variants)
Price Product not available in this region.
Shipping to

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody (2)

Additional Information
Application Details Publications Images Alternatives Variants back to top

Alternative name TP53BP1
Gene ID 7158
Immunogen A synthetic peptide, which represented a portion of human tumor protein p53 bindingprotein 1 encoded exon 19 (LocusLink ID 7158).
Cross-Reactivity Human, Mouse (Murine)
Description P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.
Specificity ABIN151771 is specific for human 53BP1 protein. Species Reactivity: Human in Western Blot andimmunocytochemistry/immunofluorescence and it reactswith Mouse in immunocytochemistry/immunofluorescence (Western Blot has not beendone using this antibody on Mouse protein). Localization: Nuclear. Associated with kinetochores. Both nuclear and cytoplasmic in some cells.

Application Details
Publications Images Alternatives Variants back to top

Application Notes Suggested working dilutions: immunofluorescence 1:200-1:1000,Western Blot 1:2000-1:10000,Immunocytochemistry 1:200-1:1000. Positive Controls: U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse)
Concentration 1 mg/ml
Purification Aff - Purified
Buffer PBS. Preservative: 0.09% Sodium Azide.
Storage Store at 4C. Do not freeze.
Research Area Transcription Factors
Restrictions For Research Use only

Publications
Application Details Images Alternatives Variants back to top

Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).

Rothkamm, Balroop, Shekhdar et al.: "Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure." in: Radiology, Vol. 242, Issue 1, pp. 244-51, 2006 (PubMed).

Ibarra, Schwob, Muendez: "Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 26, pp. 8956-61, 2008 (PubMed).

Guirouilh-Barbat, Redon, Pommier: "Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex." in: Molecular biology of the cell, Vol. 19, Issue 9, pp. 3969-81, 2008 (PubMed).

Wirthner, Wrann, Balamurugan et al.: "Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts." in: Carcinogenesis, Vol. 29, Issue 12, pp. 2306-16, 2008 (PubMed).

Palm, Hockemeyer, Kibe et al.: "Functional dissection of human and mouse POT1 proteins." in: Molecular and cellular biology, Vol. 29, Issue 2, pp. 471-82, 2008 (PubMed).

Solier, Sordet, Kohn et al.: "Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 68-82, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts Rabbit (62), Mouse (3), Goat (1)
Reactivities Human (66), Mouse (Murine) (47), Rat (Rattus) (28), Dog (Canine) (23), Cow (Bovine) (5), Horse (Equine) (5), Pig (Porcine) (5)
Applications Immunofluorescence (IF) (44), Western Blotting (WB) (27), ELISA (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunocytochemistry (ICC) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (6), Immunoprecipitation (IP) (4), Immunoelectron Microscopy (IEM) (2), Flow Cytometry (FACS) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy5.5 (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes Ser1778 (11), pSer1778 (8), pSer29,pSer25 (4), AA 1-337 (2), N-Term (2), pSer25 (2), AA 1614-1972 (1), C-Term (1), Internal Region (1), Ser25, Ser29 (1), pSer6 (1), pThr46,pThr37 (1)