Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Details for Product No. ABIN251422
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Antigen
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik, ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1
Epitope
pSer1981
(49), (15), (12), (12), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(205), (69), (39), (4), (4), (1), (1)
Host
Mouse
(149), (47), (12), (6), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(130), (51), (46), (46), (40), (39), (32), (12), (7), (4), (3), (2)
Pubmed 2 references available
Catalog no. ABIN251422
Quantity 25 µL
Price
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide with a phosphorylated serine (1981).
Clone 10H11-E12
Isotype IgG1
Specificity ABIN151772 is specific for the human ATM kinase.Phosphorylated:Ser1981. Species Reactivity: ABIN151772 reacts with human and rat protein. Localization: Nuclear. Found also in endocytic vesicles in association with beta adaptin.
Cross-Reactivity Human, Rat (Rattus)
Purification Ascites
Alternative Name ATM
Background ATM-kinase plays an important regulatory role. DNA damage caused by such things asionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions thatregulate cell cycle, apoptosis, and DNA damage repair. Alternate Names: anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylatedSer1981 antibody, anti-ATM (phospho S1981) anitbody.
Gene ID 472
Application Notes Suggested working dilutions: Western Blot 1:1,000 ,Immunocytochemistry 1:1,000. Positive Controls: Irradiated normal human fibroblasts. No reactivity against un-irradiated cell extracts.
Restrictions For Research Use only
Format Liquid
Buffer Preservative: 0.05 sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody
General Yalcin, Zhang, Luciano et al.: "Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25692-705, 2008 (PubMed).

Spardy, Duensing, Hoskins et al.: "HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies." in: Cancer research, Vol. 68, Issue 23, pp. 9954-63, 2008 (PubMed).

Hosts (149), (47), (12), (6), (3)
Reactivities (205), (69), (39), (4), (4), (1), (1)
Applications (130), (51), (46), (46), (40), (39), (32), (12), (7), (4), (3), (2)
Conjugates (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Epitopes (49), (15), (12), (12), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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