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Details for Product No. ABIN251423

Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

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Antigen
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik, ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1
Epitope
»Alternatives pSer1981
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN251423
Quantity 25 µL
Price
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Immunogen A synthetic peptide surrounding the phosphorylated serine at 1981.
Clone 10H11-E12
Isotype IgG1
Specificity Species Reactivity: ABIN151773 reacts with human ATM kinase. Other species have not been tested.
Cross-Reactivity Human
Purification Ascites
Alternative Name ATM
Background ATM-kinase plays an important regulatory role. DNA damage caused by such things asionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions thatregulate cell cycle, apoptosis, and DNA damage repair. Alternate Names: anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylatedSer 1981 antibody.
Gene ID 472
Application Notes Suggested working dilutions: Western Blot 1:1,000. Positive Controls: Irradiated normal human fibroblasts. No reactivity against un-irradiated cell extracts.
Restrictions For Research Use only
Format Liquid
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Bartek, Lukas: "DNA repair: Damage alert." in: Nature, Vol. 421, Issue 6922, pp. 486-8, 2003 (PubMed).

Bakkenist, Kastan: "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." in: Nature, Vol. 421, Issue 6922, pp. 499-506, 2003 (PubMed).

Chu, Yang, Lu et al.: "Silencing of p29 affects DNA damage responses with UV irradiation." in: Cancer research, Vol. 66, Issue 17, pp. 8484-91, 2006 (PubMed).

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts (154), (58), (18), (6), (4)
Reactivities (229), (73), (43), (5), (4), (1), (1)
Applications (142), (69), (54), (48), (43), (40), (34), (13), (10), (7), (3), (2), (2)
Conjugates (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Epitopes (52), (15), (12), (12), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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