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Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Antigen

Ataxia Telangiectasia Mutated (ATM)
Synonyms AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, AI256621, C030026E19Rik, ATM, Tefu, atm/tefu, dATM, tef, DmelCG6535, CG6535, Xatm
Binding Site
Alternatives

pSer1981
Clonality Monoclonal (10H11-E12)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN251423
Quantity 25 µL  (Variants)
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name ATM
Gene ID 472
Immunogen A synthetic peptide surrounding the phosphorylated serine at 1981.
Cross-Reactivity Human
Format Ascites
Isotype IgG1
Clone 10H11-E12
Description ATM-kinase plays an important regulatory role. DNA damage caused by such things asionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions thatregulate cell cycle, apoptosis, and DNA damage repair. Alternate Names: anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylatedSer 1981 antibody.
Specificity Species Reactivity: ABIN151773 reacts with human ATM kinase. Other species have not been tested.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:1,000. Positive Controls: Irradiated normal human fibroblasts. No reactivity against un-irradiated cell extracts.
Purification Ascites
Buffer Preservative: 0.1% sodium azide.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Bartek, Lukas: "DNA repair: Damage alert." in: Nature, Vol. 421, Issue 6922, pp. 486-8, 2003 (PubMed).

Bakkenist, Kastan: "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." in: Nature, Vol. 421, Issue 6922, pp. 499-506, 2003 (PubMed).

Chu, Yang, Lu et al.: "Silencing of p29 affects DNA damage responses with UV irradiation." in: Cancer research, Vol. 66, Issue 17, pp. 8484-91, 2006 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts Rabbit (105), Mouse (31), Goat (8), Sheep (5), Chicken (2)
Reactivities Human (145), Mouse (Murine) (72), Rat (Rattus) (54), Hamster (2), Monkey (2)
Applications Western Blotting (WB) (69), Immunofluorescence (IF) (55), ELISA (30), Immunoprecipitation (IP) (30), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (26), Immunohistochemistry (IHC) (19), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Immunocytochemistry (ICC) (8), Immunoelectron Microscopy (IEM) (3), Dot Blot (Dot) (2), Fluorescence Microscopy (FM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), HRP (3), PE (3), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes pSer1981 (41), C-Term (20), pTyr170 (18), AA 1391-1693 (4), AA 2577-3056 (4), AA 1-308 (3), AA 1980-2338 (3), AA 980-1512 (3), Ser1981 (3), N-Term (2), AA 1248-1332 (1), AA 1653-2032 (1), AA 1750-1800 (1), AA 2050-2717 (1), AA 2550-2600 (1), AA 5055-6585 (1), Internal Region (1)