CAMP Responsive Element Binding Protein 1 (CREB1) (Ser121) antibody

Details for Product No. ABIN251568
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Antigen
Synonyms creb, CREB1, Creb1, CREB, 2310001E10Rik, 3526402H21Rik, AV083133, Creb, Creb-1, creb1, zgc:55598
Epitope
Ser121
(83), (38), (30), (21), (20), (20), (15), (11), (9), (8), (7), (6), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(410), (265), (251), (75), (68), (67), (45), (8), (5), (5), (4), (1), (1), (1), (1), (1)
Host
Rabbit
(370), (57), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (10), (10), (7), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(328), (182), (161), (74), (60), (51), (32), (25), (22), (15), (11), (5), (2), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.025 mL
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Catalog No. ABIN251568
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Immunogen A phospho-peptide spanning the Ser121 phosphorylation site of human CREB
Purification affinity purified
Alternative Name CREB1
Background Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zippertranscription factor that binds the cyclic AMP response element (CRE) and activatestranscription in response to a variety of extracellular signals including neurotransmitters,hormones, membrane depolarization, and growth and neurotrophic factors. CREB isalso regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 bythe ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation. Alternate Names: anti-Active transcription factor CREB antibody, anti-cAMP responsive element bindingprotein 1 antibody, anti-CREB1 antibody, anti-MGC9284 antibody, anti-Transactivatorprotein antibody.
Gene Symbol: CREB1
Gene ID 1385
UniProt P16220
Application Notes This CREB [p Ser121] antibody is useful for Immunoprecipitation and Western blot.
Recommended dilutions: immunoprecipitation 0.5 µg, Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/mL
Buffer Tris 50 % glycerol, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
General Shi, Venkataraman, Dodson et al.: "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 16, pp. 5898-903, 2004 (PubMed).

Shi, Dodson, Shaikh et al.: "Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40195-200, 2005 (PubMed).

Dodson, Tibbetts: "DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1692-7, 2006 (PubMed).

Shanware, Trinh, Williams et al.: "Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage." in: The Journal of biological chemistry, Vol. 282, Issue 9, pp. 6283-91, 2007 (PubMed).

Shi, Dodson, Mukhopadhyay et al.: "Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies." in: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9236-43, 2007 (PubMed).

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