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CAMP Responsive Element Binding Protein 1 (CREB1) (pSer121) antibody

Antigen

CAMP Responsive Element Binding Protein 1 (CREB1)
Synonyms CREB, MGC9284, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, JAL, hJAL, ATCE1, CREB3, CREB4, AIBZIP, CREB1, creb1, MGC52669, creb, MGC69285, MGC55598, zgc:55598, Creb1, DKFZp468J2311
Binding Site
Alternatives

pSer121
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunoprecipitation (IP), Western Blotting (WB)
5 references available
Catalog no. ABIN251568
Quantity 25 µl  (0.3 mg/ml)  (Variants)
Price Product not available in this region.
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Additional Information
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Alternative name CREB1
Gene ID 1385
Immunogen A phospho-peptide spanning the Ser-121 phosphorylation site of human CREB.
Cross-Reactivity Human, Mouse (Murine)
Description Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zippertranscription factor that binds the cyclic AMP response element (CRE) and activatestranscription in response to a variety of extracellular signals including neurotransmitters,hormones, membrane depolarization, and growth and neurotrophic factors. CREB isalso regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 bythe ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation. Alternate Names: anti-Active transcription factor CREB antibody, anti-cAMP responsive element bindingprotein 1 antibody, anti-CREB1 antibody, anti-MGC9284 antibody, anti-Transactivatorprotein antibody.
Specificity This antibody is specific for the Ser-121-phosphorylated form of CREB.Phosphorylated:Ser121. Species Reactivity: Reacts with human and mouse CREB. Other species have not been tested. Localization: Nuclear.

Application Details
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Application Notes Suggested working dilutions: immunoprecipitation 0.5 ug,Western Blot 1:500
Concentration 0.3 mg/ml
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Shi, Venkataraman, Dodson et al.: "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 16, pp. 5898-903, 2004 (PubMed).

Shi, Dodson, Shaikh et al.: "Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40195-200, 2005 (PubMed).

Dodson, Tibbetts: "DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1692-7, 2006 (PubMed).

Shanware, Trinh, Williams et al.: "Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage." in: The Journal of biological chemistry, Vol. 282, Issue 9, pp. 6283-91, 2007 (PubMed).

Shi, Dodson, Mukhopadhyay et al.: "Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies." in: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9236-43, 2007 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "CAMP Responsive Element Binding Protein 1 (CREB1)", type "Antibodies"
Hosts Rabbit (177), Mouse (50)
Reactivities Human (215), Rat (Rattus) (150), Mouse (Murine) (140), Pig (Porcine) (60), Cow (Bovine) (59), Sheep (Ovine) (59), Chicken (57), Dog (Canine) (49), Horse (Equine) (15), Monkey (5), Xenopus laevis (4), Zebrafish (2), Zebrafish (Danio rerio) (2), Cat (Feline) (1)
Applications Western Blotting (WB) (144), ELISA (71), Immunofluorescence (IF) (70), Immunohistochemistry (IHC) (70), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (44), Immunoprecipitation (IP) (20), Immunocytochemistry (ICC) (11), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Flow Cytometry (FACS) (5), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Dot Blot (DB) (1), Electrophoretic Mobility-Shift Assay (EMSA) (1), Gel Shift (GS) (1)
Conjugates Alexa Fluor 488 (7), Alexa Fluor 350 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), PE,Cy5.5 (6), Biotin (5), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes pSer133 (33), pSer129 (16), pSer142 (9), N-Term (6), Ser129 (5), pSer121 (5), Internal Region (4), Ser133 (4), pS133 (2), phosphospecific (2), AA 1-96 (1), AA 100-150 (1), AA 122-147,pSer133 (1), AA 136-341 (1), AA 152-179 (1), AA 5-24 (1), AA 5-45 (1), Center (1), Ser142 (1), Thr100 (1), pSer129, pSer133 (1), pThr100 (1), pThr244 (1), pTyr766 (1)