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Details for Product No. ABIN251624

BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody

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Synonyms BACH1, FANCJ, OF, 3110009N10Rik, 8030460J03Rik, Bach1, FACJ, Fancj, MGC68622, BRIP1, fancj, si:ch211-158l18.1
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN251624
Quantity 25 µL
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Immunogen A synthetic peptide within the extreme C-terminus of the human BACH1/Brip1 proteinsequence.
Specificity This antibody is specific for BACH1/Brip1. Species Reactivity: ABIN151876 recognizes human Brip1. Localization: Nuclear.
Cross-Reactivity Human
Alternative Name BRIP1 / FANCJ
Background BRIP1 (also called BACH1) is a helicase that interacts with the BRCT domain of BRCA1and has a role in BRCA1-dependent DNA repair and checkpoint. BRIP1 has recentlybeen found to be defective in Fanconi anemia complementation group J. BRIP1/FANCJhas a function in the Fanconi anemia pathway that is independent of BRCA1 anddownstream of FANCD2 activation. (1-4). Alternate Names: anti-FANCJ protein antibody, anti-BACH 1 antibody, anti-BACH1 BRIP1 antibody,anti-BRIP 1 antibody, anti-BRAC 1 Associated C Terminal Helicase 1 antibody,anti-BRCA 1 Interacting Protein 1 antibody, anti- Fanconi anemia group J protein.
Gene ID 83990
Application Notes Immunoprecipitation 2-4 ul,Western Blot 1:2,000-1:3,000. Positive Controls: HeLa whole cell extract [NB 800-PC1], and Raji, 293, MCF7 and SKOV3 whole cellextracts.
Restrictions For Research Use only
Ohira, Seki, Nagase et al.: "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1." in: Genomics, Vol. 47, Issue 2, pp. 300-6, 1998 (PubMed).

Cantor, Bell, Ganesan et al.: "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function." in: Cell, Vol. 105, Issue 1, pp. 149-60, 2001 (PubMed).

Bridge, Vandenberg, Franklin et al.: "The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair." in: Nature genetics, Vol. 37, Issue 9, pp. 953-7, 2005 (PubMed).

Alternatives for antigen "BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1)", type "Antibodies"
Hosts (42), (18), (1)
Reactivities (58), (28), (24), (12), (12), (12), (12), (12)
Applications (39), (20), (13), (11), (8), (6), (2), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (6), (4), (3), (2), (2), (2), (1), (1), (1)