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BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody

Antigen

BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1)
Synonyms OF, BACH1, FANCJ, FLJ90232, MGC126521, MGC126523, Bach1, 3110009N10Rik, 8030460J03Rik, MGC68622, BRIP1, fancj, si:ch211-158l18.1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunoprecipitation (IP), Western Blotting (WB)
3 references available
Catalog no. ABIN251624
Quantity 25 µl  (Variants)
Price Product not available in this region.
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anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody

anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibody (2)

Additional Information
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Alternative name BRIP1 / FANCJ
Gene ID 83990
Immunogen A synthetic peptide within the extreme C-terminus of the human BACH1/Brip1 proteinsequence.
Cross-Reactivity Human
Description BRIP1 (also called BACH1) is a helicase that interacts with the BRCT domain of BRCA1and has a role in BRCA1-dependent DNA repair and checkpoint. BRIP1 has recentlybeen found to be defective in Fanconi anemia complementation group J. BRIP1/FANCJhas a function in the Fanconi anemia pathway that is independent of BRCA1 anddownstream of FANCD2 activation. (1-4). Alternate Names: anti-FANCJ protein antibody, anti-BACH 1 antibody, anti-BACH1 BRIP1 antibody,anti-BRIP 1 antibody, anti-BRAC 1 Associated C Terminal Helicase 1 antibody,anti-BRCA 1 Interacting Protein 1 antibody, anti- Fanconi anemia group J protein.
Specificity This antibody is specific for BACH1/Brip1. Species Reactivity: ABIN151876 recognizes human Brip1. Localization: Nuclear.

Application Details
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Application Notes Immunoprecipitation 2-4 ul,Western Blot 1:2,000-1:3,000. Positive Controls: HeLa whole cell extract [NB 800-PC1], and Raji, 293, MCF7 and SKOV3 whole cellextracts.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Restrictions For Research Use only

Publications
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Ohira, Seki, Nagase et al.: "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1." in: Genomics, Vol. 47, Issue 2, pp. 300-6, 1998 (PubMed).

Cantor, Bell, Ganesan et al.: "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function." in: Cell, Vol. 105, Issue 1, pp. 149-60, 2001 (PubMed).

Bridge, Vandenberg, Franklin et al.: "The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair." in: Nature genetics, Vol. 37, Issue 9, pp. 953-7, 2005 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1)", type "Antibodies"
Hosts Rabbit (34), Mouse (8), Chicken (1)
Reactivities Human (43), Mouse (Murine) (24), Rat (Rattus) (24), Chicken (19), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (19), Pig (Porcine) (19)
Applications Immunofluorescence (IF) (21), Western Blotting (WB) (19), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes C-Term (4), pSer990 (4), AA 1233-1249 (2), N-Term (2), AA 92-104 (1), pThr401 (1)