Add to Basket
Order hotline:
 |
+1 404 474 4654 |
 |
+1 888 205 9894 (TF) |
Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody
| Antigen | Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) |
| Synonyms | HIF1, MOP1, PASD8, bHLHe78, HIF-1alpha, HIF1-ALPHA, FIH1, FLJ20615, FLJ22027, DKFZp762F1811, 2310046M24Rik, A830014H24Rik, HIF1A, HIF-1a, HIF1a, hif-1a, hif1a |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus) |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
 |
2 references available |
| Catalog no. | ABIN251630 |
| Quantity | 25 µL (1 mg/ml) (Variants) |
| Price | Product not available in this region. |
| Shipping to |
|
Additional Information
| Alternative name | HIF1AN / FIH1 |
| Gene ID | 3091 |
| Immunogen | A C-terminal region synthetic peptide made to the human FIH protein sequence(between residues 300 and the C-terminus). |
| Cross-Reactivity | Human, Rat (Rattus) |
| Description | Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activityby binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alphatransactivation function by recruiting histone deacetylases. Involvement of VHL inassociation with FIH provides a unifying mechanism for the modulation of HIF-1 alphaprotein stabilization and transcriptional activation in response to changes in cellularoxygen concentration. Alternate Names: anti-FIH antibody, anti-FIH1 antibody, anti-HIF1AN antibody, anti-Hypoxia-induciblefactor 1 alpha inhibitor antibody, anti-Hypoxia-inducible factor asparagine hydroxylaseantibody, anti-prolyl hydroxylase antibody, anti-FIH-1 antibody. |
| Specificity | This antibody is specific for FIH-1 protein. Species Reactivity: Human and rat. Localization: Nuclear. |
Application Details
| Application Notes | Suggested working dilutions: immunohistochemistry 1:100 ,Western Blot 1:1,000-1:5,000. Positive Controls: Rat astrocytes and C6 and U251 gliomas |
| Concentration | 1 mg/ml |
| Purification | Affinity Purified |
| Buffer | Preservative: 0.1% sodium azide. |
| Storage | Store at 4C. Do not freeze. |
| Restrictions | For Research Use only |
Images
Publications
|
Birle, Hedley: "Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors." in: Cancer research, Vol. 67, Issue 4, pp. 1735-43, 2007 (PubMed).
Li, Wang, Dutta et al.: "Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7345-53, 2007 (PubMed). |
|
Alternatives
Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN)", type "Antibodies"
| Hosts | Rabbit (46), Mouse (4) |
| Reactivities | Human (51), Mouse (Murine) (27), Rat (Rattus) (26), Cow (Bovine) (22), Dog (Canine) (22), Chicken (19), Pig (Porcine) (18), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1) |
| Applications | Western Blotting (WB) (32), ELISA (20), Immunofluorescence (IF) (17), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Flow Cytometry (FACS) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1) |
| Conjugates | Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1) |
| Epitopes | N-Term (7), C-Term (5), Internal Region (2), Middle Region (1) |
