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Details for Product No. ABIN251630

Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) antibody

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Synonyms FIH1, 2310046M24Rik, A830014H24Rik, cb728, id:ibd5139, HIF-1a, HIF1a, hif-1a, hif1a
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN251630
Quantity 25 µL
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Immunogen A C-terminal region synthetic peptide made to the human FIH protein sequence(between residues 300 and the C-terminus).
Specificity This antibody is specific for FIH-1 protein. Species Reactivity: Human and rat. Localization: Nuclear.
Cross-Reactivity Human, Rat (Rattus)
Purification Affinity Purified
Alternative Name HIF1AN / FIH1
Background Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activityby binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alphatransactivation function by recruiting histone deacetylases. Involvement of VHL inassociation with FIH provides a unifying mechanism for the modulation of HIF-1 alphaprotein stabilization and transcriptional activation in response to changes in cellularoxygen concentration. Alternate Names: anti-FIH antibody, anti-FIH1 antibody, anti-HIF1AN antibody, anti-Hypoxia-induciblefactor 1 alpha inhibitor antibody, anti-Hypoxia-inducible factor asparagine hydroxylaseantibody, anti-prolyl hydroxylase antibody, anti-FIH-1 antibody.
Gene ID 3091
Application Notes Suggested working dilutions: immunohistochemistry 1:100 ,Western Blot 1:1,000-1:5,000. Positive Controls: Rat astrocytes and C6 and U251 gliomas
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Birle, Hedley: "Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors." in: Cancer research, Vol. 67, Issue 4, pp. 1735-43, 2007 (PubMed).

Li, Wang, Dutta et al.: "Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7345-53, 2007 (PubMed).

Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN)", type "Antibodies"
Hosts (55), (15)
Reactivities (69), (32), (28), (16), (15), (12), (12), (2), (2)
Applications (59), (19), (18), (13), (11), (10), (4), (3), (3), (1), (1)
Conjugates (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (10), (3), (3), (2), (2), (2), (1)