TNFSF11 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 11) (AA 1-317)

Details for Product anti-TNFSF11 Antibody No. ABIN252476, Supplier: Log in to see
Antigen
  • TNFSF11
  • BTF3L1
  • HUMBTFB
  • OCIF
  • OPG
  • TNFRSF11B
  • CD254
  • ODF
  • OPGL
  • OPTB2
  • RANKL
  • TRANCE
  • hRANKL2
  • sOdf
  • Ly109l
  • Trance
  • Opg
  • tumor necrosis factor (ligand) superfamily, member 11
  • basic transcription factor 3 pseudogene 11
  • tumor necrosis factor receptor superfamily, member 11b
  • TNFSF11
  • BTF3P11
  • Tnfsf11
  • Tnfrsf11b
  • TNFRSF11B
Alternatives
anti-Human TNFSF11 antibody for Enzyme Immunoassay
Epitope
AA 1-317
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15
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11
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1
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1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
251
185
80
3
2
1
1
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Host
Mouse
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96
37
8
1
Clonality (Clone)
Monoclonal ()
Conjugate
This TNFSF11 antibody is un-conjugated
28
13
10
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5
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2
Application
Chromatin Immunoprecipitation (ChIP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
254
121
96
80
52
36
26
25
23
14
14
7
5
4
3
3
3
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen A bacterially expressed fusion protein containing amino acid residues 1-317 of mouse TRANCE was used as immunogen (NP_003692).
Clone 12A668
Isotype IgG1 kappa
Purification Protein G purified
Alternative Name CD254 / RANKL (TNFSF11 Antibody Abstract)
Background Gene Symbol: TNFSF11
Molecular Weight Theoretical MW: 35 kDa
Gene ID 8600
UniProt O14788
Pathways NF-kappaB Signaling
Application Notes Western Blot 0.5-2 μg/mL, Flow Cytometry, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin 5 μg/mL, Chromatin Immunoprecipitation (ChIP)Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.Use in chromatin immunoprecipitation reported in scientific literature (PMID 25859979) The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Western Blot: TRANCE/RANKL Antibody (12A668) [ABIN252476] - Western blot analysis of ...
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Immunohistochemistry: TRANCE/RANKL Antibody (12A668) [ABIN252476] - Immunohistochemic...
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Western Blot: TRANCE/TNFSF11/RANK L Antibody (12A668) [ABIN2524762] - Analysis of tra...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody (12A668) [ABIN2524762] ...
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Western Blot: TRANCE/TNFSF11/RANK L Antibody (12A668) [ABIN2524762] - Analysis of hum...
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Western Blot: TRANCE/TNFSF11/RANK L Antibody (12A668) [ABIN2524762] - Analysis using ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody (12A668) [ABIN2524762] ...
Immunofluorescence (IF) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody (ABIN252476) Immunocytochemistry/Immunofluorescence: TRANCE/TNFSF11/RANK L Antibody (12A668) - TR...
Product cited in: Shao, Zhang, Yang, Qi, Zhang, Deng: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting,Chromatin Immunoprecipitation

Mine, Makihira, Yamaguchi, Tanaka, Nikawa: "Involvement of ERK and p38 MAPK pathways on Interleukin-33-induced RANKL expression in osteoblastic cells." in: Cell biology international, Vol. 38, Issue 5, pp. 655-62, 2014 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Callegari, Coons, Ricks, Rosenfeld, Scatena: "Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6." in: Journal of vascular research, Vol. 51, Issue 2, pp. 118-31, 2014 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Yin, Schluesener, Zhang, Zhang: "Lesional infiltration of receptor activator of nuclear factor-κB ligand⁺ cells in experimental autoimmune neuritis rats." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 34, Issue 6, pp. 905-9, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunohistochemistry

Gambichler, Terras, Kampilafkos, Kreuter, Skrygan: "T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge." in: The British journal of dermatology, Vol. 169, Issue 6, pp. 1288-94, 2013 (PubMed). (Sample species: Human). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Kim, Oh, Lee, Seo, Hwang, Kim: "The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption." in: Biomaterials, Vol. 35, Issue 6, pp. 1869-81, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Hu, Chung, Berel, Frierson, Yang, Liu, Wang, Li, Rogatko, Zhau: "Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study." in: PLoS ONE, Vol. 8, Issue 9, pp. e73081, 2013 (PubMed). (Sample species: Human).

Boyce, Chong, Yao, Gafni, Kelly, Chamberlain, Bassim, Cherman, Ellsworth, Kasa-Vubu, Farley, Molinolo, Bhattacharyya, Collins: "Denosumab treatment for fibrous dysplasia." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 27, Issue 7, pp. 1462-70, 2012 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Shin, Matsuo, Tada, Fukushima, Furuta, Ozeki, Kadowaki, Yamamoto, Okamoto, Jimi: "The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells." in: Carcinogenesis, Vol. 32, Issue 11, pp. 1634-40, 2011 (PubMed).

Hu, Chu, Zhu, Yang, Luthringer, Prins, Habib, Wang, Wang, Chung, Zhau: "Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer." in: PLoS ONE, Vol. 6, Issue 12, pp. e28670, 2011 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence,Immunohistochemistry

Neidhart, Baraliakos, Seemayer, Zelder, Gay, Michel, Boehm, Gay, Braun: "Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis." in: Annals of the rheumatic diseases, Vol. 68, Issue 8, pp. 1334-9, 2009 (PubMed). (Sample species: Human). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Ghoreishi, Bach, Obst, Komba, Fleet, Dutz: "Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6071-8, 2009 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Parrula, Zimmerman, Nadella, Shu, Rosol, Fernandez, Lairmore, Niewiesk: "Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia." in: Veterinary pathology, Vol. 46, Issue 5, pp. 1003-14, 2009 (PubMed). (Sample species: Human). Further details: Cell Sorting,Flow Cytometry

Sandra, Hendarmin, Kukita, Nakao, Nakamura, Nakamura: "Ameloblastoma induces osteoclastogenesis: a possible role of ameloblastoma in expanding in the bone." in: Oral oncology, Vol. 41, Issue 6, pp. 637-44, 2005 (PubMed). Further details: ELISA

Niida, Kawahara, Ishizuka, Ikeda, Kondo, Hibi, Suzuki, Ikeda, Taniguchi: "Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5752-6, 2004 (PubMed).

Rubin, Chung, Fan, Zhu, Murphy, Nanes, Rosen: "Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis." in: The Prostate, Vol. 58, Issue 1, pp. 41-9, 2003 (PubMed).

Kikuchi, Matsuguchi, Tsuboi, Mitani, Tanaka, Matsuoka, Yamamoto, Hishikawa, Noguchi, Yoshikai: "Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3574-9, 2001 (PubMed).

Pearse, Sordillo, Yaccoby, Wong, Liau, Colman, Michaeli, Epstein, Choi: "Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11581-6, 2001 (PubMed).

Fiumara, Snell, Li, Mukhopadhyay, Younes, Gillenwater, Cabanillas, Aggarwal, Younes: "Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines." in: Blood, Vol. 98, Issue 9, pp. 2784-90, 2001 (PubMed).

Hsu, Lacey, Dunstan, Solovyev, Colombero, Timms, Tan, Elliott, Kelley, Sarosi, Wang, Xia, Elliott, Chiu, Black, Scully, Capparelli, Morony, Shimamoto, Bass, Boyle: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

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