Baculoviral IAP Repeat-Containing 7 (BIRC7) antibody

Details for Product No. ABIN252506, Supplier: Log in to see
Antigen
  • TIAP2
  • zgc:165605
  • EIAP/XLX
  • XLX
  • kiap
  • livin
  • ml-iap
  • mliap
  • rnf50
  • xEIAP
  • KIAP
  • LIVIN
  • ML-IAP
  • MLIAP
  • RNF50
  • RGD1562883
  • E130019N06
  • Livin
  • baculoviral IAP repeat-containing 5-like
  • baculoviral IAP repeat containing 7
  • baculoviral IAP repeat-containing 7
  • baculoviral IAP repeat-containing 7 (livin)
  • Birc5l
  • BIRC7
  • birc7
  • Birc7
Reactivity
Human
174
29
26
5
3
3
1
Host
Mouse
113
41
21
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
141
52
45
35
34
30
13
9
8
3
2
2
1
1
1
1
1
1
Options
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Supplier Product No.
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Immunogen Recombinant human livin protein was used as immunogen.
Clone 88C570
Isotype IgG1 kappa
Specificity The Livin antibody, clone 88C570 has been shown to recognize both Livin alpha (~39 kDa) and Livin beta (~37 kDa) isoforms (Nachmias et al, 2003). 2. The antibody also recognizes the 30 kDa (p30-Livin alpha) and 28 kDa (p28-Livin beta) apoptotic cleavage fragments of Livin alpha and beta, respectively (Nachmias et al, 2003). Apoptotic cleavage fragments of Livin have also been referred to as truncated livin (tLivin) (Nachmias et al, 2007). 3. The specificity of the antibody has been validated using Livin shRNA (Quiping et al, 2004).
Purification Protein G purified
Alternative Name Livin (BIRC7 Antibody Abstract)
Background Gene Symbol: BIRC7
Gene ID 79444
UniProt Q96CA5
Research Area Apoptosis/Necrosis, Cancer
Application Notes Western Blot 1-2 μg/mL, Immunocytochemistry/Immunofluorescence 2-5 μg/mLImmunocytochemistry/Immunofluorescence see Nachmias et al, 2007
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05 % BSA
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) antibody (ABIN252506) Western blot detection of Livin in A) Livin transfected cell lysate and B) U266 cell ...
Western Blotting (WB) image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) antibody (ABIN252506) Western Blot: Livin Antibody (88C570) [ABIN2525068] - detection of Livin in A) Livin ...
Product cited in: Tchoghandjian, Soubéran, Tabouret, Colin, Denicolaï, Jiguet-Jiglaire, El-Battari, Villard, Baeza-Kallee, Figarella-Branger: "Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152." in: Cell death & disease, Vol. 7, Issue 8, pp. e2325, 2016 (PubMed). (Sample species: Human). Further details: Western Blotting

Shiloach, Berens, Danke, Waiskopf, Perlman, Ben-Yehuda: "tLivin displays flexibility by promoting alternative cell death mechanisms." in: PLoS ONE, Vol. 9, Issue 6, pp. e101075, 2014 (PubMed). (Sample species: Human). Further details: Western Blotting

Lazar, Perlman, Lotem, Peretz, Ben-Yehuda, Kadouri: "The clinical effect of the inhibitor of apopotosis protein livin in melanoma." in: Oncology, Vol. 82, Issue 4, pp. 197-204, 2012 (PubMed).

Liu, Wang, Gao, Yuan, Jiao: "Expression and role of the inhibitor of apoptosis protein livin in chemotherapy sensitivity of ovarian carcinoma." in: International journal of oncology, Vol. 41, Issue 3, pp. 1021-8, 2012 (PubMed).

Slagsvold, Pettersen, Størvold, Follestad, Krokan, Schønberg: "DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells." in: Nutrition and cancer, Vol. 62, Issue 5, pp. 611-21, 2010 (PubMed). (Sample species: Human). Further details: Western Blotting

Fakler, Loeder, Vogler, Schneider, Jeremias, Debatin, Fulda: "Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance." in: Blood, Vol. 113, Issue 8, pp. 1710-22, 2009 (PubMed). (Sample species: Human). Further details: Western Blotting

Lazar, Yaacov, Shiloach, Eliahoo, Kadouri, Lotem, Perlman, Zakay-Rones, Panet, Ben-Yehuda: "The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein Livin." in: Journal of virology, Vol. 84, Issue 1, pp. 639-46, 2009 (PubMed). (Sample species: Human). Further details: Western Blotting

Choi, Hwang, Sung, Lee, Yoo, Jung, Koo, Kim, Kang, Shin, Ahn: "Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia." in: Blood, Vol. 109, Issue 2, pp. 471-7, 2007 (PubMed). Further details: Western Blotting

Gordon, Mani, Mukhopadhyay, Dong, Edenfield, Glickman, Yeap, Sugarbaker, Bueno: "Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma." in: The Journal of pathology, Vol. 211, Issue 4, pp. 447-54, 2007 (PubMed). (Sample species: Human).

Gordon, Mani, Mukhopadhyay, Dong, Yeap, Sugarbaker, Bueno: "Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma." in: The Journal of pathology, Vol. 211, Issue 4, pp. 439-46, 2007 (PubMed). (Sample species: Human).

Crnković-Mertens, Wagener, Semzow, Gröne, Haferkamp, Hohenfellner, Butz, Hoppe-Seyler: "Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis." in: Cellular and molecular life sciences : CMLS, Vol. 64, Issue 9, pp. 1137-44, 2007 (PubMed). (Sample species: Human).

Nachmias, Lazar, Elmalech, Abed-El-Rahaman, Asshab, Mandelboim, Perlman, Ben-Yehuda: "Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin." in: Apoptosis : an international journal on programmed cell death, Vol. 12, Issue 7, pp. 1129-42, 2007 (PubMed). Further details: Immunocytochemistry,Western Blotting,Immunofluorescence

Kleinberg, Lie, Flørenes, Nesland, Davidson: "Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma." in: Human pathology, Vol. 38, Issue 7, pp. 986-94, 2007 (PubMed). (Sample species: Human). Further details: Western Blotting

Wang, Tan, Wang, Liu, Yu, Bai, He, Zhao: "Silencing livin gene by siRNA leads to apoptosis induction, cell cycle arrest, and proliferation inhibition in malignant melanoma LiBr cells." in: Acta pharmacologica Sinica, Vol. 28, Issue 12, pp. 1968-74, 2007 (PubMed). (Sample species: Human). Further details: Western Blotting

Crnkovi?-Mertens, Semzow, Hoppe-Seyler, Butz: "Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells." in: Journal of molecular medicine (Berlin, Germany), Vol. 84, Issue 3, pp. 232-40, 2006 (PubMed).

Ma, Huang, Song, Feng, Tian, Du, Qiu, Heese, Wu: "Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway." in: Cell death and differentiation, Vol. 13, Issue 12, pp. 2079-88, 2006 (PubMed). Further details: Western Blotting

Qiuping, Jie, Youxin, Qun, Wei, Chun, Jin, Yan, Chunsong, Mingzhen, Qingping, Qun, Kejian, Zhimin, Junyan, Jinquan: "Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia." in: Oncogene, Vol. 24, Issue 4, pp. 573-84, 2005 (PubMed). Further details: Western Blotting

Yang, Du: "Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells." in: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 16963-70, 2004 (PubMed). Further details: Western Blotting

Qiuping, Jei, Youxin, Wei, Chun, Jin, Qun, Yan, Chunsong, Mingzhen, Qingping, Kejian, Zhimin, Qun, Junyan, Jinquan: "CC chemokine ligand 25 enhances resistance to apoptosis in CD4+ T cells from patients with T-cell lineage acute and chronic lymphocytic leukemia by means of livin activation." in: Cancer research, Vol. 64, Issue 20, pp. 7579-87, 2004 (PubMed). Further details: Western Blotting

Nachmias, Ashhab, Bucholtz, Drize, Kadouri, Lotem, Peretz, Mandelboim, Ben-Yehuda: "Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma." in: Cancer research, Vol. 63, Issue 19, pp. 6340-9, 2003 (PubMed). Further details: Western Blotting

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