Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) (AA 1085-1115) antibody (Biotin)

Details for Product No. ABIN2559700, Supplier: Log in to see
Antigen
  • CILP
  • im:7137994
  • CILP-1
  • HsT18872
  • 9830114D16
  • C130036G17Rik
  • NTPPH
  • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
  • ClpX caseinolytic peptidase X homolog (E. coli)
  • CILP
  • cilp
  • CLPX
  • LOC100224477
  • Cilp
Epitope
AA 1085-1115
11
5
5
4
3
3
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
28
18
11
3
1
1
1
1
1
Host
Rabbit
18
17
6
3
Clonality
Polyclonal
Conjugate
Biotin
5
3
2
1
1
1
Application
Western Blotting (WB)
34
30
6
2
2
2
2
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human CILP
Isotype IgG
Specificity The immunogen falls within the Cartilage intermediate layer protein 1 C2 region.
Purification Purified by Protein A.
Alternative Name CILP (CILP Antibody Abstract)
Background

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Subcellular location: Secreted

Synonyms: CILP-1, HsT18872, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, CILP, UNQ602/PRO1188

Gene ID 8483
UniProt O75339
Research Area Signaling, Extracellular Matrix
Application Notes WB 1:100-1000
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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