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CILP antibody (AA 1051-1184) (HRP)

CILP Reactivity: Human, Rat WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal HRP
Catalog No. ABIN2559701
  • Target See all CILP Antibodies
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Binding Specificity
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1184
    Reactivity
    • 25
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 19
    • 4
    • 2
    • 2
    Rabbit
    Clonality
    • 24
    • 3
    Polyclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CILP antibody is conjugated to HRP
    Application
    • 24
    • 14
    • 13
    • 13
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    The immunogen falls within the Cartilage intermediate layer protein 1 C2 region.
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CILP
    Isotype
    IgG
    Top Product
    Discover our top product CILP Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Alternative Name
    CILP (CILP Products)
    Synonyms
    CILP-1 antibody, HsT18872 antibody, 9830114D16 antibody, C130036G17Rik antibody, NTPPH antibody, CILP antibody, im:7137994 antibody, cartilage intermediate layer protein antibody, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase antibody, cartilage intermediate layer protein 1 antibody, CILP antibody, Cilp antibody, cilp antibody, LOC100336614 antibody
    Background

    Synonyms: CILP-1, HsT18872, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, CILP, UNQ602/PRO1188

    Background: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

    Gene ID
    8483
    UniProt
    O75339
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