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SAG antibody (pSer412)

SAG Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2567047
  • Target See all SAG Antibodies
    SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))
    Binding Specificity
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer412
    Reactivity
    • 26
    • 8
    • 7
    • 4
    • 3
    • 1
    Human
    Host
    • 24
    • 6
    • 1
    Rabbit
    Clonality
    • 26
    • 5
    Polyclonal
    Conjugate
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SAG antibody is un-conjugated
    Application
    • 18
    • 13
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412.
    Purification
    Antibodies were purified by affinity-chromatography using epitope-specific peptide.
    Immunogen
    Arrestin 1 (phospho Ser412) antibody was raised against a peptide sequence around phosphorylation site of Serine 412 (T-G-S (p)-P-Q) derived from Human Arrestin 1.
    Isotype
    IgG
    Top Product
    Discover our top product SAG Primary Antibody
  • Application Notes
    Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store antibody at -20°C for up to one year.
  • Target
    SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))
    Alternative Name
    Arrestin 1 (SAG Products)
    Synonyms
    RP47 antibody, S-AG antibody, MGC75721 antibody, MGC84416 antibody, sag antibody, zgc:114197 antibody, SAGMR antibody, SANTI antibody, ARR antibody, sag1 antibody, A930001K18Rik antibody, Arr1 antibody, Irbp antibody, arrestin antibody, S-antigen visual arrestin antibody, S-antigen antibody, S-antigen; retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) S homeolog antibody, S-antigen; retina and pineal gland (arrestin) b antibody, S-antigen, retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) L homeolog antibody, SAG antibody, PF10_0343 antibody, sag antibody, sag.S antibody, sagb antibody, Sag antibody, sag.L antibody
    Background
    Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein, the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
    Molecular Weight
    50 kDa
    Gene ID
    408
    NCBI Accession
    NP_004032
    UniProt
    P49407
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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