INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist, this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.
Purification
INPP4B antibody is affinity chromatography purified via peptide column.
Immunogen
INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B.
E130107I17Rik antibody, inositol polyphosphate-4-phosphatase, type II antibody, inositol polyphosphate-4-phosphatase type II B antibody, Inpp4b antibody, INPP4B antibody
Background
Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3).