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Details for Product No. ABIN257695

Sphingosine Kinase 1 (SPHK1) antibody

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Synonyms SPHK, Sk1, Spk1, 1110006G24Rik, CG1747, Dmel\\CG1747, SK1, Sphk1, SPHK1, F18E5.160, F18E5_160, sphingosine kinase 1
»Alternatives Mouse (Murine)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA
Pubmed 2 references available
Catalog no. ABIN257695
Quantity 0.1 mg
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Immunogen Synthetic peptide with sequence SWKPQQMPPPEEPL, representing the C-Terminus ofthe human protein according to NP_068807. Reference Sequence: NP_068807.
Isotype IgG
Specificity Species Reactivity: Cross-reacts with Human. Not yet tested in other species.
Cross-Reactivity Mouse (Murine)
Purification Aff - Purified
Background SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate(SPP), a lipid mediator which has both intra- and extracellular functions. Intracellularly,SPP regulates proliferation and survival. Extracellularly it functions as a ligand forEDG1. SPHK1 also acts on D-erythro-sphingosine and to a lesser extent sphinganine,but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine,diacylglycerol, ceramide, or phosphatidylinositol. Competitive inhibitors of SPHK blockformation of SPP and selectively inhibit cellular proliferation induced by a variety offactors, including platelet-derived growth factor and serum. SPHK1 has also been foundto mediate TRAF2 activation (Xia et al 2002). TRAF2 is a member of the TNF receptorassociated family and is required for TNF-alpha activation of MAPK8/JNK and NFkB.SPHK1 is widely expressed, with highest levels in adult liver, kidney, heart and skeletalmuscle. Alternate Names: anti-Sphingosine Kinase 1 antibody, anti-SPHK antibody.
Gene ID 8877, 20698
NCBI Accession NP_068807
Application Notes This antibody can be used in Western Blot. Recommended Starting Dilutions*:WB: 1-3 ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline containing [pH7.3] with 0.5% BSA. Preservative: 0.02% Na azide.
Preservative Sodium azide
Storage -20 °C
Kohama, Olivera, Edsall et al.: "Molecular cloning and functional characterization of murine sphingosine kinase." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23722-8, 1998 (PubMed).

Igarashi, Okada, Hayashi et al.: "Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46832-9, 2003 (PubMed).

Alternatives for antigen "Sphingosine Kinase 1 (SPHK1)", type "Antibodies"
Hosts (88), (14), (4)
Reactivities (87), (32), (32), (15), (13), (2), (2)
Applications (72), (28), (23), (11), (11), (10), (3), (3), (3), (1), (1)
Conjugates (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (10), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)