Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) (N-Term), (AA 5-18) antibody

Details for Product No. ABIN257782
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Antigen
Synonyms PTP4A3, AV088979, Prl-3, pPtp4a3, PRL-3, PRL-R, PRL3, wu:fc54b05, wu:fv52d11, zgc:77109, prl-3, prl3, ptpcaax3
Epitope
N-Term, AA 5-18
(13), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (28), (16), (13), (13), (1), (1), (1), (1), (1)
Host
Goat
(58), (6), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(59), (21), (10), (4), (3), (3)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN257782
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Immunogen Synthetic peptide with sequence NRPAPVEVSYKHMR, representing the N Terminus from the second Met of the protein (residues 5-18 according to NP_009010, NP_116000.
Isotype IgG
Specificity This antibody is expected to recognise both reported isoforms (NP_009010.2 and NP_116000.1).
Cross-Reactivity (Details) Expected cross reactivity from sequence similarity: Mouse, Rat
Purification affinity purified
Alternative Name PRL3 / PTP4A3
Background The protein encoded by this gene belongs to a small class of prenylated protein tyrosinephosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in avariety of cellular processes. This class of PTPs contain a PTP domain and acharacteristic C-terminal prenylation motif. Studies of this class of PTPs in micedemonstrated that they were prenylated proteins in vivo, which suggested theirassociation with cell plasma membrane. Overexpression of this gene in mammaliancells was reported to inhibit angiotensin-II induced cell calcium mobilization and promotecell growth. Two alternatively spliced variants exist. Alternate Names: anti-Potentially prenylated protein tyrosine phosphatase antibody, anti-PRL3 antibody,anti-PRLR antibody, anti-Protein tyrosine phosphatase 4a3 antibody, anti-Proteintyrosine phosphatase of regenerating liver 3 antibody, anti-Protein tyrosine phosphatasetype IVA member 3 antibody, anti-Protein tyrosine phosphatase type IVA protein 3antibody, anti-PRL-3 antibody.
Gene Symbol: PTP4A3
Gene ID 11156
NCBI Accession NP_009010, NP_116000
Application Notes This antibody is useful for Western Blot and peptide ELISA. Approx 22kDakDa band observed in Human Pancreas lysates (calculated MW of 19.5Da according to NP_116000.1).
Recommended dilutions: Peptide ELISA detection limit 1:64000, Western Blot 0.03 µg/mL
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline containing [pH 7.3] with 0.5 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) (N-Term), (AA 5-18) antibody ABIN257782 staining (2µg/ml) of Human Pancreas lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
General Fagerli, Holt, Holien et al.: "Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells." in: Blood, Vol. 111, Issue 2, pp. 806-15, 2008 (PubMed).

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