Nanog Homeobox (NANOG) antibody

Details for Product No. ABIN258263
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Antigen
Synonyms ENK, ecat4, 2410002E02Rik
Reactivity
Human, Pig (Porcine)
(130), (40), (20), (15), (3), (1), (1)
Host
Goat
(98), (42), (12), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(127), (74), (38), (29), (21), (13), (13), (10), (6), (3), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN258263
Quantity 0.1 mg
Price
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Immunogen Peptide with sequence C-QNQRMKSKRWQKNN, from the internal region of the proteinsequence according to NP_079141.1. Reference Sequence: NP_079141.1.
Specificity This antibody is specific to the NANOG protein. Species Reactivity: Reacts with Human, Mouse, Rat, and Dog.
Cross-Reactivity Dog (Canine), Human
Purification Affinity Purified
Alternative Name NANOG
Background Nanog is a newly identified homeodomain-bearing transcriptional factor. Nanogexpression is specific to early embryos and pluripotential stem cells including mouseand human embryonic stem (ES) and embryonic germ (EG) cells. It is a key moleculeinvolved in the signaling pathway for maintaining the capacity for self-renewal andpluripotency, bypassing regulation by the STAT3 pathway. Nanog mRNA is present inpluripotent mouse and human cell lines, and absent from differentiated cells.Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonicendoderm lineage. Thus it is one of the molecular markers suitable for recognizing theundifferentiated state of stem cells in the mouse and human.NANOG is a new marker for testicular carcinoma in situ and germ cell tumors.Nanog is a 304 amino acid polypeptide which lacks a signal sequence for secretion. Alternate Names: anti-Nanog homeobox antibody, anti-ENK antibody, anti-Early Embryo specificexpression NK family gene antibody, anti-Embryonic stem cell specific homeoboxprotein (Nanog) antibody, anti-Homeobox transcription factor Nanog antibody.
Gene ID 79923, 71950, 414065
NCBI Accession NP_0791411
Application Notes Suggested working dilutions: ELISA 1:64000,Western Blot 0.03-0.1 ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, pH7.3 with 0.5% bovine serum albumin. Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Nanog Homeobox (NANOG) antibody (0.03ug/ml) staining of Human Ovary lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-Nanog Homeobox (NANOG) antibody (2) (5ug/ml) staining (green) parts of a colony of induced pluriform stem cells derived from Human Keratinocytes. Data kindly provided by CMRB, Center of Regenerative Medicine in Barcelona, Spain.
General Aasen, Raya, Barrero et al.: "Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes." in: Nature biotechnology, Vol. 26, Issue 11, pp. 1276-84, 2008 (PubMed).

Hosts (98), (42), (12), (3)
Reactivities (130), (40), (20), (15), (3), (1), (1)
Applications (127), (74), (38), (29), (21), (13), (13), (10), (6), (3), (1), (1)
Conjugates (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (9), (8), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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