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Details for Product No. ABIN258263

Nanog Homeobox (NANOG) antibody

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Synonyms ENK, ecat4, 2410002E02Rik
»Alternatives Human, Pig (Porcine)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN258263
Quantity 0.1 mg
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Immunogen Peptide with sequence C-QNQRMKSKRWQKNN, from the internal region of the proteinsequence according to NP_079141.1. Reference Sequence: NP_079141.1.
Specificity This antibody is specific to the NANOG protein. Species Reactivity: Reacts with Human, Mouse, Rat, and Dog.
Cross-Reactivity Dog (Canine), Human
Purification Affinity Purified
Alternative Name NANOG
Background Nanog is a newly identified homeodomain-bearing transcriptional factor. Nanogexpression is specific to early embryos and pluripotential stem cells including mouseand human embryonic stem (ES) and embryonic germ (EG) cells. It is a key moleculeinvolved in the signaling pathway for maintaining the capacity for self-renewal andpluripotency, bypassing regulation by the STAT3 pathway. Nanog mRNA is present inpluripotent mouse and human cell lines, and absent from differentiated cells.Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonicendoderm lineage. Thus it is one of the molecular markers suitable for recognizing theundifferentiated state of stem cells in the mouse and human.NANOG is a new marker for testicular carcinoma in situ and germ cell tumors.Nanog is a 304 amino acid polypeptide which lacks a signal sequence for secretion. Alternate Names: anti-Nanog homeobox antibody, anti-ENK antibody, anti-Early Embryo specificexpression NK family gene antibody, anti-Embryonic stem cell specific homeoboxprotein (Nanog) antibody, anti-Homeobox transcription factor Nanog antibody.
Gene ID 79923, 71950, 414065
NCBI Accession NP_0791411
Application Notes Suggested working dilutions: ELISA 1:64000,Western Blot 0.03-0.1 ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, pH7.3 with 0.5% bovine serum albumin. Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage -20 °C
Aasen, Raya, Barrero et al.: "Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes." in: Nature biotechnology, Vol. 26, Issue 11, pp. 1276-84, 2008 (PubMed).

Alternatives for antigen "Nanog Homeobox (NANOG)", type "Antibodies"
Hosts (102), (38), (13), (3)
Reactivities (132), (39), (19), (15), (3), (2), (1), (1)
Applications (131), (83), (37), (31), (22), (13), (13), (10), (6), (6), (1)
Conjugates (7), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (11), (9), (6), (6), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)