Pyruvate Dehydrogenase Complex, Component X (PDHX) (AA 204-284) antibody

Details for Product No. ABIN258270
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Antigen
Synonyms zgc:66110, zgc:85977, MGC86218, PDHX, DDBDRAFT_0168431, DDBDRAFT_0230192, DDB_0168431, DDB_0230192, DLDBP, E3BP, OPDX, PDX1, proX, AI481367, E3bp, Pdx1, Ac1164
Epitope
AA 204-284
(4), (3), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(34), (20), (16), (12), (1)
Host
Rabbit
(28), (4), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(25), (12), (10), (9), (6), (3), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.05 mL
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Catalog No. ABIN258270
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Immunogen GST fusion protein corresponding to residues 204-284 of mouse PDX1.
Purification Whole antisera
Alternative Name PDHX / PDX1
Background PDX1 (Pancrease/duodenum homeobox 1, Insulin promoter factor 1, IPF1,Islet/duodenum homeobox 1, IDX1, Somatatostatin transactivating factor 1, STF1,Insulin upstream factor 1, UUF1, Glucose-sensitive factor, GSF) activates transcriptionof the insulin and somatostain genes. PDX1 is required for maintaining thehormone-producing phenotype of the beta-cell. Alternate Names: anti-Glucose sensitive factor antibody, anti-GSF antibody, anti-IDX 1 antibody, anti-IDX1antibody, anti-Insulin promoter factor 1 antibody, anti-insulin promoter factor 1homeodomain transcription factor antibody, anti-insulin upstream factor 1 antibody,anti-IPF1 antibody, anti-Islet/duodenum homeobox 1 antibody, anti-IUF 1 antibody,anti-IUF1 antibody, anti-MODY4 antibody, anti-Pancreas/duodenum homeobox 1antibody, anti-PDX 1 antibody, anti-Somatostatin transactivating factor 1 antibody,anti-STF 1 antibody, anti-STF1 antibody.
Gene Symbol: PDX1
Gene ID 3651
Application Notes Recommended dilutions: Chromatin Immunoprecipitation 1:10-1:500, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunoprecipitation 1:10-1:500, Western Blot 1:1000-1:2000
Restrictions For Research Use only
Format Liquid
Buffer Whole rabbit antiserum containing 30 % glycerol, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Supplier Images
anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) (AA 204-284) antibody Mouse pancreatic beta T cell lysate was probed with anti-PDX1 (1:20,000 dilution). Arrow indicates PDX1.
General Stoffers, Zinkin, Stanojevic et al.: "Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence." in: Nature genetics, Vol. 15, Issue 1, pp. 106-10, 1997 (PubMed).

Ahlgren, Jonsson, Jonsson et al.: "beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes." in: Genes & development, Vol. 12, Issue 12, pp. 1763-8, 1998 (PubMed).

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