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Details for Product No. ABIN258507

alpha Tubulin / TUBA4A / TUBA1 antibody

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Antigen
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
Application
»Alternatives Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN258507
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide: HGIQPDGQMPSDKT, corresponding to N terminal amino acids28-41 of Human alpha TubulinBLAST ',HGIQPDGQMPSDKT',.
Clone EP1332Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues near the N-term of human. Species Reactivity: Reacts in human, mouse, and rat. Not tested in other species.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Ascites
Background Microtubules are essential parts in eukaryotic cell structures, transportation, and mitosis.It consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta tubulinbinds to alpha tubulin to form tubulin heterodimer which is post-translationally modified(1). The tubulin dimer complex binds to GTP and assembles onto the positive ends ofmicrotubules. After incorporation into the microtubules, bound GTP is hydrolyzed bybeta tubulin. The stability of the dimer in the microtubules is depended on presence ofbeta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubuleincorporation (2). For both type of tubulin, the carboxy-terminal tail is pos-translationallymodified to regulate associated protein binding at microtubule surface (3). A mutation onalpha tubulin has been linked to abnormal neuronal migration and neurodevelopmentaldisorders in human (4). Alternate Names: anti-Alpha tubulin ubiquitous antibody, anti-H2 ALPHA antibody, anti-TUBA1 antibody,anti-Tubulin alpha 1 chain antibody, anti-Tubulin alpha antibody, anti-Tubulin alpha ubiquitous chain antibody, anti-Tubulin K alpha 1 antibody.
Gene ID 7277, 22143, 500929
UniProt P68363
Application Notes WB: 1:50,000, IHC: 1:250
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25 mM EDTA, 25 mM CitricAcid, and 0.5% BS. Preservative: 0.25% sodium azide.
Preservative Sodium azide
Storage -20 °C
Lee, Deng, Wang et al.: "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 51, pp. 20350-5, 2007 (PubMed).

Alternatives for antigen "alpha Tubulin / TUBA4A / TUBA1", type "Antibodies"
Hosts (15), (5)
Reactivities (13), (7), (4), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Applications (17), (9), (9), (3), (3), (3), (2), (1), (1)
Epitopes (1), (1)
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