Microtubules are essential parts in eukaryotic cell structures, transportation, and mitosis.It consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta tubulinbinds to alpha tubulin to form tubulin heterodimer which is post-translationally modified(1). The tubulin dimer complex binds to GTP and assembles onto the positive ends ofmicrotubules. After incorporation into the microtubules, bound GTP is hydrolyzed bybeta tubulin. The stability of the dimer in the microtubules is depended on presence ofbeta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubuleincorporation (2). For both type of tubulin, the carboxy-terminal tail is pos-translationallymodified to regulate associated protein binding at microtubule surface (3). A mutation onalpha tubulin has been linked to abnormal neuronal migration and neurodevelopmentaldisorders in human (4). Alternate Names: anti-Alpha tubulin ubiquitous antibody, anti-H2 ALPHA antibody, anti-TUBA1 antibody,anti-Tubulin alpha 1 chain antibody, anti-Tubulin alpha antibody, anti-Tubulin alpha ubiquitous chain antibody, anti-Tubulin K alpha 1 antibody.