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Endonuclease G (ENDOG) (C-Term) antibody

Antigen

Endonuclease G (ENDOG)
Synonyms FLJ27463, CG8862, DmelCG8862, ENDOG, Tb08.10J17.140, Tb08.10J17.90, TBC1D13, endog
Binding Site
Alternatives

C-Term
Clonality Monoclonal (EP1665Y)
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN258669
Quantity 0.1 ml
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives back to top

Alternative name Endonuclease G
Gene ID 2021, 13804, 362100
UniProt Q14249
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Isotype IgG
Clone EP1665Y
Description Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to thenucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatinDNA into nucleosomal fragments independently of caspases. Therefore, endoGrepresents a caspase-independent apoptotic pathway initiated from the mitochondria(1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported tobe important for both nuclear DNA fragmentation during apoptosis and mitochondrialDNA replication. Findings indicate that EndoG is essential during early embryogenesisand plays a critical role in normal apoptosis and nuclear DNA fragmentation (2). Alternate Names: anti-Endo G antibody.
Specificity A synthetic peptide corresponding to residues on the C-terminus of human Endo G wasused as an immunogen. Species Reactivity: Cross reacts with human, mouse, and rat.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:2000 - 5000
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Li, Luo, Wang: "Endonuclease G is an apoptotic DNase when released from mitochondria." in: Nature, Vol. 412, Issue 6842, pp. 95-9, 2001 (PubMed).

Zhang, Dong, Li et al.: "Endonuclease G is required for early embryogenesis and normal apoptosis in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15782-7, 2003 (PubMed).

Szczesny, Tann, Longley et al.: "Long patch base excision repair in mammalian mitochondrial genomes." in: The Journal of biological chemistry, Vol. 283, Issue 39, pp. 26349-56, 2008 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Endonuclease G (ENDOG)", type "Antibodies"
Hosts Rabbit (40), Mouse (13)
Reactivities Human (49), Rat (Rattus) (38), Mouse (Murine) (36), Cow (Bovine) (1), Dog (Canine) (1), Xenopus laevis (1), Zebrafish (1)
Applications Western Blotting (WB) (38), ELISA (16), Immunofluorescence (IF) (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes AA 76-170 (4), C-Term (4), N-Term (2), AA 55-70 (1), Internal Region (1)