anti-Endonuclease G antibody (ENDOG) (C-Term)

Details for Product anti-ENDOG Antibody No. ABIN258669
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

(12), (11), (8), (6), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1)
(102), (62), (52), (1), (1), (1), (1)
(65), (40)
Clonality (Clone)
Monoclonal ()
This Endonuclease G antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(90), (38), (14), (10), (9), (6), (6), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States ( )
Availability Please contact our customer support.
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen A synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.
Clone EP1665Y
Isotype IgG
Purification Tissue culture supernatant
Alternative Name Endonuclease G (ENDOG Antibody Abstract)
Background Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to thenucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatinDNA into nucleosomal fragments independently of caspases. Therefore, endoGrepresents a caspase-independent apoptotic pathway initiated from the mitochondria(1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported tobe important for both nuclear DNA fragmentation during apoptosis and mitochondrialDNA replication. Findings indicate that EndoG is essential during early embryogenesisand plays a critical role in normal apoptosis and nuclear DNA fragmentation (2). Alternate Names: anti-Endo G antibody.
Gene Symbol: ENDOG
Gene ID 2021, 13804, 362100
Pathways Apoptosis Pathway
Application Notes This product is useful for: Western Blot. In Western blot this antibody detects a band at approximately 35kDa.
Recommended dilutions: Western Blot 1:2000-5000
Restrictions For Research Use only
Format Liquid
Buffer PBS 49 % , Glycerol 50 % , BSA 0.05 % , Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
General Szczesny, Tann, Longley et al.: "Long patch base excision repair in mammalian mitochondrial genomes." in: The Journal of biological chemistry, Vol. 283, Issue 39, pp. 26349-56, 2008 (PubMed).

Zhang, Dong, Li et al.: "Endonuclease G is required for early embryogenesis and normal apoptosis in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15782-7, 2003 (PubMed).

Li, Luo, Wang: "Endonuclease G is an apoptotic DNase when released from mitochondria." in: Nature, Vol. 412, Issue 6842, pp. 95-9, 2001 (PubMed).

Validation Images
Catalog No. ABIN258669
$ 496.10
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?