Endonuclease G (ENDOG) (C-Term) antibody

Details for Product No. ABIN258669
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Antigen
Synonyms wu:fb79c08, zgc:110020, CG8862, Dmel\\CG8862, Tb08.10J17.140, Tb08.10J17.90, TBC1D13, endog, ENDOG
Epitope
C-Term
(8), (8), (7), (4), (4), (3), (3), (1), (1), (1)
Reactivity
Human
(85), (61), (51), (13), (13), (12), (12), (1), (1)
Host
Rabbit
(52), (37)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(79), (44), (12), (10), (8), (8), (3), (2), (1)
Pubmed 3 references available
Catalog no. ABIN258669
Quantity 0.1 mL
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Clone EP1665Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues on the C-terminus of human Endo G wasused as an immunogen. Species Reactivity: Cross reacts with human, mouse, and rat.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Alternative Name Endonuclease G
Background Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to thenucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatinDNA into nucleosomal fragments independently of caspases. Therefore, endoGrepresents a caspase-independent apoptotic pathway initiated from the mitochondria(1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported tobe important for both nuclear DNA fragmentation during apoptosis and mitochondrialDNA replication. Findings indicate that EndoG is essential during early embryogenesisand plays a critical role in normal apoptosis and nuclear DNA fragmentation (2). Alternate Names: anti-Endo G antibody.
Gene ID 2021, 13804, 362100
UniProt Q14249
Application Notes Suggested working dilutions: Western Blot 1:2000 - 5000
Restrictions For Research Use only
Format Liquid
Storage -20 °C
General Li, Luo, Wang: "Endonuclease G is an apoptotic DNase when released from mitochondria." in: Nature, Vol. 412, Issue 6842, pp. 95-9, 2001 (PubMed).

Zhang, Dong, Li et al.: "Endonuclease G is required for early embryogenesis and normal apoptosis in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15782-7, 2003 (PubMed).

Szczesny, Tann, Longley et al.: "Long patch base excision repair in mammalian mitochondrial genomes." in: The Journal of biological chemistry, Vol. 283, Issue 39, pp. 26349-56, 2008 (PubMed).

Hosts (52), (37)
Reactivities (85), (61), (51), (13), (13), (12), (12), (1), (1)
Applications (79), (44), (12), (10), (8), (8), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (8), (7), (4), (4), (3), (3), (1), (1), (1)
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