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Details for Product No. ABIN258713

Defensin, alpha 5, Paneth Cell-Specific (DEFA5) antibody

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Antigen
Synonyms DEFA1, DEF5, HD-5, Defa29, Defcr5, Defcr29, Defcr24, Defcr4, Rd5, defensin 6, defensin 7, defensin-5, DEFA5
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN258713
Quantity 25 µL
Price
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Immunogen Full-length proHD5 protein. [Swiss-Prot# Q01523] The propeptide is the full-length protein. In the mature form, it is cleaved at residue 63(alanine).
Clone 8C8
Isotype IgG2b
Specificity This antibody is specific for HD5. It does not cross-react with HD6, lysozyme or sPLA2. Species Reactivity: This antibody reacts with human HD5 protein. Other species have not been tested. Localization: Secreted protein.
Cross-Reactivity Human
Purification Purified
Alternative Name Defensin alpha 5
Background Human neutrophil alpha-defensins (also designated HNPs) are small, cationic,cysteine-rich antimicrobial proteins that play important roles in innate immunity againstinfectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins aresynthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7.Paneth cells in small intestinal crypts secrete the alpha-defensins, which are alsotermed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innatedefense of the GI mucosal surface by protecting against microbial invasion in states ofintestinal inflammation. Alternate Names: anti-HD5 antibody, anti-Defensin 5 antibody, anti-Defensin, alpha 5 antibody,anti-DEFA5 antibody, anti-DEF5 antibody. Related Diseases: Crohn',s Disease
Gene ID 1670
Application Notes Suggested working dilutions: Immunohistochemistry-Paraffin 5-10 ug/ml
Restrictions For Research Use only
Concentration 2.35 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage -20 °C
Wehkamp, Salzman, Porter et al.: "Reduced Paneth cell alpha-defensins in ileal Crohn's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 50, pp. 18129-34, 2005 (PubMed).

Alternatives for antigen "Defensin, alpha 5, Paneth Cell-Specific (DEFA5)", type "Antibodies"
Hosts (27), (21)
Reactivities (44), (12), (12), (3)
Applications (35), (23), (17), (12), (10), (5), (4), (3), (3), (2), (2), (2), (1)
Conjugates (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (4), (1), (1), (1), (1)
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