Apolipoprotein E (APOE) antibody

Details for Product No. ABIN258785
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Antigen
Synonyms AD2, LDLCQ5, LPG, AI255918, APOEA, Apo-E, ad2, apoprotein, im:7036787, wu:fb69a05, zgc:110064, apoe
Reactivity
Human
(169), (42), (31), (5), (4), (2), (2), (2), (1)
Host
Mouse
(100), (63), (52), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (8), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(157), (130), (56), (42), (20), (17), (16), (15), (10), (9), (8), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN258785
Quantity 0.1 mL
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Immunogen Purified human ApoE. [Uniprot# P02649].
Clone WUE-4
Isotype IgG1
Specificity Species Reactivity: Human. Though not tested, it is likely to react with mouse. It does not appear to reactwith rat brain tissue. Other species have not been tested. Localization: Secreted.
Cross-Reactivity Human
Purification Purified
Alternative Name Apolipoprotein E (Apo E)
Background Lipoproteins are responsible for carrying cholesterol and other fats through thebloodstream as little packages and are essential for the normal breakdown of thesemolecules. In particular, apolipoprotein E is a major component of specific lipoproteinscalled very low-density lipoproteins (VLDL). A major function of VLDLs is to removeexcess cholesterol from the blood and carry it to the liver for processing. Maintainingnormal levels of cholesterol is essential for the prevention of cardiovascular diseases,including heart attacks and strokes.Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with severalcardiovascular disorders. There are three isoforms (slightly different forms) of the ApoElipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to beone of several genetic factors that plays a part in increased risk of heart attacks andstrokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has beenbeen suggested to play a role in type 2 Alzheimer disease. Alternate Names: anti-Apolipoprotein E antibody, anti-Apo-E antibody. Related Diseases: Alzheimer's Disease, Atherosclerosis, Coronary Artery Disease
Gene ID 348
UniProt P02649
Research Area Metabolism
Application Notes Suggested working dilutions: immunohistochemistry 2 ug/ml,Western Blot 2 ug/ml. Positive Controls: Human brain and liver lysate
Restrictions For Research Use only
Format Liquid
Concentration 0.85 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Apolipoprotein E (APOE) antibody anti-Apolipoprotein E (APOE) antibody
General Krul, Tikkanen, Schonfeld: "Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function." in: Journal of lipid research, Vol. 29, Issue 10, pp. 1309-25, 1989 (PubMed).

Fryer, Demattos, McCormick et al.: "The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice." in: The Journal of biological chemistry, Vol. 280, Issue 27, pp. 25754-9, 2005 (PubMed).

Wahrle, Jiang, Parsadanian et al.: "Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43236-42, 2005 (PubMed).

Hosts (100), (63), (52), (1)
Reactivities (169), (42), (31), (5), (4), (2), (2), (2), (1)
Applications (157), (130), (56), (42), (20), (17), (16), (15), (10), (9), (8), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Conjugates (14), (8), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (13), (5), (4), (3), (2), (1), (1)
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