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Details for Product No. ABIN258876

Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3) antibody

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Antigen
Synonyms 4.1B, DAL-1, DAL1, DAL1P, Dal1, Epb41l3, NBL3, Epb4.1l3, Kiaa0987, EPB4.1L3, EPB41L1
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN258876
Quantity 0.1 mL
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Immunogen A synthetic peptide made to an internal region of the human protein (within residues400-500). [Swiss-Prot# Q9Y2J2].
Specificity Species Reactivity: Reacts with human, mouse, rat and Xenopus. Theoretical Molecular Weight: 120 kDa (isoform A), 96 kDa (isorform B).
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name EPB41L3
Background Protein 4.1B is a member of a family of similar proteins whose expression is frequentlylost in a variety of human tumors, including meningiomas, non-small-cell lung cancers,and breast carcinomas and is frequently down-regulated in human clinical prostatecancer. Studies have shown that Protein 4.1B normally triggers death in metastaticcells, thereby preventing cancer from spreading. A clinical test for Protein 4.1B activitycould be useful in assessing the metastatic potential of prostate cancers. Alternate Names: anti-4.1B antibody, anti-Differentially expressed in adenocarcinoma of the lung protein 1antibody, anti-DAL-1 antibody, anti-EPB41L3 antibody, anti-DAL1 antibody,anti-KIAA0987 antibody, anti-EPB41L3 antibody. Related Diseases: Prostate Cancer
Gene ID 23136, 13823, 116724
UniProt Q9Y2J2
Research Area Cancer, Cytoskeleton, Microfilaments
Application Notes Suggested working dilutions: Western Blot 2 ug/ml. Positive Controls: Human and mouse brain lysate, HeLa whole cell lysate
Restrictions For Research Use only
Format Liquid
Concentration 1.15 mg/ml
Buffer PBS, 30% glycerol. Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
McCarty, Cook, Hynes: "An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 38, pp. 13479-83, 2005 (PubMed).

Wong, Haack, Kissil et al.: "Protein 4.1B suppresses prostate cancer progression and metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12784-9, 2007 (PubMed).

Alternatives for antigen "Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3)", type "Antibodies"
Hosts (27), (6), (5)
Reactivities (35), (20), (20), (14), (12), (12), (12), (7)
Applications (26), (11), (10), (4), (2), (1), (1)
Conjugates (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (5), (3), (2), (2), (1)
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