Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3) antibody

Antigen: Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3)

Synonyms: 4.1B, DAL1, DAL-1, FLJ37633, KIAA0987, 4.1-G, DKFZp781D1972, DKFZp781H1755, 4.1N, KIAA0338, MGC11072, DKFZp686H17242, EPB41L1, DKFZp469A1823

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN258877

Additional Information

Alternative name: EPB41L3

Gene ID: 23136

Immunogen: A synthetic peptide made to an internal region of the human protein (within residues400-500). [Swiss-Prot# Q9Y2J2].

Cross-Reactivity: Human, Mouse (Murine)

Description: Protein 4.1B is a member of a family of similar proteins whose expression is frequentlylost in a variety of human tumors, including meningiomas, non-small-cell lung cancers,and breast carcinomas and is frequently down-regulated in human clinical prostatecancer. Studies have shown that Protein 4.1B normally triggers death in metastaticcells, thereby preventing cancer from spreading. A clinical test for Protein 4.1B activitycould be useful in assessing the metastatic potential of prostate cancers. Alternate Names: anti-4.1B antibody, anti-Differentially expressed in adenocarcinoma of the lung protein 1antibody, anti-DAL-1 antibody, anti-EPB41L3 antibody, anti-DAL1 antibody,anti-KIAA0987 antibody. Related Diseases: Prostate Cancer

Specificity: Species Reactivity: Reacts with human, mouse, rat and Xenopus. Theoretical Molecular Weight: 120 kDa (isoform A), 96 kDa (isorform B).

Application Details

Application Notes: Suggested working dilutions: Western Blot 2 ug/ml. Positive Controls: Human and mouse brain lysate, HeLa whole cell lysate

Concentration: 1.15 mg/ml

Purification: Aff - Purified

Buffer: PBS, 30% glycerol. Preservative: 0.1% sodium azide.

Storage: Store at 4C for short-term. Aliquot and store at -20C for long-term. Avoid freeze-thawcycles.

Research Area: Cancer, Cytoskeleton, Microfilaments

Restrictions: For Research Use only

Images

Detection of Band 4.1 in HeLa whole cell lysate using ABIN258876.

Detection of Band 4.1 in mouse brain lysate using ABIN258876.

Publications

McCarty, Cook, Hynes: "An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 38, pp. 13479-83, 2005 (PubMed).

Wong, Haack, Kissil et al.: "Protein 4.1B suppresses prostate cancer progression and metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12784-9, 2007 (PubMed).