Striatin (STRN) antibody

Details for Product No. ABIN259101
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Antigen
Synonyms SG2NA, AU022939, D130055P19
Reactivity
Human
(11), (8), (8)
Host
Rabbit
(12)
Clonality
Polyclonal
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(12), (5), (5), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN259101
Quantity 0.1 mL
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Immunogen Synthetic peptide made to an internal portion of the human protein (within residues350-400). [Swiss-Prot# O43815].
Specificity This antibody does not cross-react with SG2NA. Species Reactivity: Human, mouse and rat. Localization: Cell Membrane and Cytoplasmic.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Serum
Alternative Name Striatin / STRN
Background Striatin is found in all mammalian cells assayed and may be involved in vesiculartransport, dendrite growth, and cellular signaling. It binds Protein phosphatase 2A(PP2A) A and C subunits and calmodulin and appears to modulate PP2A activity. Italso binds the human homolog of the yeast protein, Mob1, which has been implicated inmitotic progression in yeast. It is a member of a family of proteins that also includesSG2NA and Zinedin. This antibody does not cross-react with SG2NA. Alternate Names: anti-STRN antibody, anti-MGC125642 antibody, anti-SG2NA antibody, anti-striatincalmodulin binding protein antibody.
Gene ID 29966, 268980, 29149
UniProt Q13033
Application Notes Suggested working dilutions: immunofluorescence 1:5000,Western Blot 1:500-1:5000
Restrictions For Research Use only
Format Liquid
Buffer Preservative: Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Striatin (STRN) antibody Immunofluorescent staining of NIH3T3 cells ± blocking peptide using ABIN259101.
anti-Striatin (STRN) antibody (2) Immunoblot of PP2A immunoprecipitate with ABIN259101.
General Moreno, Park, Nelson et al.: "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5257-63, 2000 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Moreno, Lane, Pallas: "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24253-60, 2001 (PubMed).

Hosts (12)
Reactivities (11), (8), (8)
Applications (12), (5), (5), (2), (1), (1)
Epitopes (2), (2), (1), (1)
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