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Striatin (STRN) (AA 350-400) antibody

Details for Product No. ABIN259102
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Antigen
Synonyms SG2NA, AU022939, D130055P19
Epitope
AA 350-400
(7), (7), (2), (1), (1)
Reactivity
Human
(17), (8), (8)
Host
Rabbit
(18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
(18), (8), (5), (5), (1), (1)
Pubmed 3 references available
Quantity 0.025 mL
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Catalog No. ABIN259102
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Immunogen Synthetic peptide made to an internal portion of the human Striatin protein (within residues 350-400).
Specificity This antibody specific for Striatin. It does not cross-react with SG2NA.
Purification Whole antisera
Alternative Name Striatin / STRN
Background Striatin is found in all mammalian cells assayed and may be involved in vesiculartransport, dendrite growth, and cellular signaling. It binds Protein phosphatase 2A(PP2A) A and C subunits and calmodulin and appears to modulate PP2A activity. Italso binds the human homolog of the yeast protein, Mob1, which has been implicated inmitotic progression in yeast. It is a member of a family of proteins that also includesSG2NA and Zinedin. This antibody does not cross-react with SG2NA. Alternate Names: anti-STRN antibody.
Gene Symbol: STRN
Gene ID 6801
UniProt O43815
Application Notes This Striatin antibody is useful in Western blot, Immunocytochemistry/Immunofluorescence and Immunoprecipitation. In WB a band can be seen at ~110 kDa.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:5000, Immunoprecipitation 1:10-1:500, Western Blot 1:500-1:5000
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
anti-Striatin (STRN) (AA 350-400) antibody Immunofluorescent staining of NIH3T3 cells ± blocking peptide using ABIN259101.
anti-Striatin (STRN) (AA 350-400) antibody (2) Immunoblot of PP2A immunoprecipitate with ABIN259101.
General Moreno, Park, Nelson et al.: "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5257-63, 2000 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Moreno, Lane, Pallas: "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24253-60, 2001 (PubMed).

Validation Images
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