Striatin (STRN) antibody

Antigen: Striatin (STRN)

Synonyms: SG2NA, MGC125642, AU022939, D130055P19

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)

Catalog no.: ABIN259102

Additional Information

Alternative name: Striatin / STRN

Gene ID: 6801

Immunogen: Synthetic peptide made to an internal portion of the human protein (within residues350-400). [Swiss-Prot# O43815].

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Format: Serum

Description: Striatin is found in all mammalian cells assayed and may be involved in vesiculartransport, dendrite growth, and cellular signaling. It binds Protein phosphatase 2A(PP2A) A and C subunits and calmodulin and appears to modulate PP2A activity. Italso binds the human homolog of the yeast protein, Mob1, which has been implicated inmitotic progression in yeast. It is a member of a family of proteins that also includesSG2NA and Zinedin. This antibody does not cross-react with SG2NA. Alternate Names: anti-STRN antibody.

Specificity: This antibody does not cross-react with SG2NA. Species Reactivity: Human, mouse and rat. Localization: Cell Membrane and Cytoplasmic.

Application Details

Application Notes: Suggested working dilutions: immunofluorescence 1:5000,Western Blot 1:500-1:5000

Purification: Serum

Buffer: Preservative: Sodium Azide.

Storage: Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thawcycles.

Restrictions: For Research Use only

Images

Immunofluorescent staining of NIH3T3 cells ± blocking peptide using ABIN259101.

Immunoblot of PP2A immunoprecipitate with ABIN259101.

Publications

Moreno, Park, Nelson et al.: "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5257-63, 2000 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Moreno, Lane, Pallas: "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24253-60, 2001 (PubMed).