Striatin, Calmodulin Binding Protein 3 (STRN3) antibody

Antigen: Striatin, Calmodulin Binding Protein 3 (STRN3)

Synonyms: SG2NA, Gs2na, striatin-3, Sg2na, STRN3, MGC151634, GS2NA, KIAA1333, MGC175239, id:ibd1241, wu:fc02f06, si:dz115o7.2, si:dz234g15.7, si:busm1-115o7.2, MGC145300, strn, MGC80575

Clonality: Monoclonal (S68)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)

Catalog no.: ABIN259103

Additional Information

Alternative name: Striatin-3 / SG2NA

Immunogen: Synthetic peptide made to an internal portion of the human protein (within residues200-300). [Swiss-Prot# Q13033].

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Format: Ascites

Isotype: IgG1

Clone: S68

Description: SG2NA was identified as a human cancer autoantigen and has now been implicated invesicular trafficking and signal transduction. It is highly related to striatin and zinedin. Itis a scaffolding protein that binds PP2A A and C subunits as well as the human homologof the yeast protein, Mob1, which has been implicated in control of mitotic progression inyeast. It also binds calmodulin and appears to modulate PP2A activity. Alternate Names: anti-Striatin-3 antibody, anti- Cell-cycle autoantigen SG2NA antibody, anti-S/G2 antigenantibody, anti-STRN3 antibody, anti-GS2NA antibody.

Specificity: This antibody does not cross-react with Striatin. Species Reactivity: Human, mouse and rat. Localization: Cytoplasm and membrane.

Application Details

Application Notes: Suggested working dilutions: immunofluorescence 1:5000,Western Blot 1:250-1:2000

Purification: Ascites

Buffer: Preservative: Sodium Azide.

Storage: Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thawcycles.

Restrictions: For Research Use only

Images

Detection of SG2NA in NIH3T3 cell lysates using ABIN259103.

Immunofluorescent staining of NIH3T3 cells using ABIN259103.

Publications

Moreno, Park, Nelson et al.: "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5257-63, 2000 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Moreno, Lane, Pallas: "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24253-60, 2001 (PubMed).